Another Stem Cell and CCSVI success story was 9.5 EDSS scale

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Another Stem Cell and CCSVI success story was 9.5 EDSS scale

Postby milesap » Wed Sep 19, 2012 4:57 pm

http://www.facebook.com/debie.oconnell#!/debie.oconnell

Deb O'Connell was assessed at 9.5 on the EDSS when she arrived at the clinic last week. She could not take solid foods through the mouth and the airlines had to extend her special permission to travel. Her other disabilities are significant. If anyone cares to see how she's doing 5 days post-first procedure, and in between therapies, you can log into her Facebook at:

To make a long story short, Deb's brainfog is gone and she's speaking clearly where she could hardly talk before, swallowing again, able to take solid foods, and after 10 years has gotten out of her powerchair and is now taking several steps many times during the day and already working with the clinic physiotherapist. Even the clinic staff is amazed. Many tears of joy are being shed. Even at this level of disability, the improvements happen so fast for some. She will be getting another round of stem cells in 2 days.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby MarkW » Thu Sep 20, 2012 4:53 am

Hello Milesap/Tony
CSSVI and stem cells is an interesting topic. To keep the thread together I suggest you use one thread for your posts as it helps people wanting to follow the subject. As you created the thread you can always go to the first post and edit the title to keep the topic up to date.
Personally I want to know more about the clinic in India before I make a judgement.
Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby milesap » Thu Sep 20, 2012 7:38 am

I agree that the India location may be suspect because they are not giving stats on the number of treated what types of MS and failures all this has to be taken lightly for now. I don't know moving this announcement from CCSVI serves any purpose because the treatment starts as CCSVI and then moves to Stem cells so I'm not sure if it should stay here or go to General Discussion. It seems that it belongs here because the treatment of CCSVI with stem cells is the initial treatment.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby MarkW » Thu Sep 20, 2012 8:37 am

Hello Tony,
I tried to suggest that you put the CCSVI and Stem Cells in one thread under CCSVI. See Vit D3 and De-stenosis as an example. My thread may deviate a bit but it has lots of info on CCSVI and VitD. I feel it would help readers to group threads on CCSVI and Stem Cells in one long thread. Takes work from you but it helps newbies in particular.
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby 1eye » Thu Sep 20, 2012 9:01 am

It would be good to have all these stem cell stories under one *thread* (they are still CCSVI stories too, so no one is saying don't use the forum). That way you might get a general impression of just how many success stories there are. One or two swallows don't make a summer. On the other hand, it all sounds very promising. This is one case where doctors and researchers being honest and forthcoming about failures and a few statistics would be of great help. Nobody ever won a Nobel prize by keeping secrets. More often nobody will listen to the truth.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby milesap » Mon Sep 24, 2012 4:43 am

If there is another patient history I'll start another thread, the problem is I would be accused of bill boarding if I move this to another location.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby milesap » Sat Sep 29, 2012 8:36 pm

CCSVI Clinic Combination Autologous Stem Cell Therapy - Deb O'Connell
http://www.youtube.com/watch?v=JVCK_KxHoe8
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby milesap » Tue Oct 02, 2012 9:26 am

Posting made by Lisa Chapil on the CCSVI Locator: http://ccsvi-ms.ning.com/profiles/blogs ... atients-in

Scientific Innovations Lead to Improved Outcomes for Patients in Study- Deb O’Connell Case Study
Posted by Lisa Chapil on October 2, 2012 at 8:56am
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Over the past year, CCSVI Clinic and its researchers and specialists have been studying the Combination venoplasty/autologous stem cell infusion protocol developed by Regenetek Cellular Technologies with the collaboration of outside labs and bioproducts manufacturers. As laboratory techniques gain ever-increasing sophistication based on new scientific methodologies for enhancing somatic cells into preferred lineages in vitro, the therapeutic outcomes for patients with neurological disorders have also been improving. Deb O’Connell who was treated at the Clinic in mid-September, 2012 recovered so quickly from her serious long-term degenerative disease condition that she experienced a wave of improvements while still in the hospital.
It’s a matter of medical record that Deb had been wheelchair bound for 10 years (completely non-ambulatory) with multiple co-morbidities when she entered the program on September 9; she was 9.5 on the EDSS scale as assessed by a neurologist, was down to 80 lbs in body weight, could not breathe effectively, speak, or take in food by mouth due to dysphagia. Her pain was chronic and significant. When she left the Clinic on September 24th , she walked out of the doors and into a waiting van to go to the airport. At the time of her discharge from the Clinic, she could breathe normally, effectively speak once again, eat any types of food she desired and her pain had all but disappeared. At the time of this writing she is back home in Canada and reports that she continues to recover (especially her contractured hands), shows no signs of new disease symptoms, and has gained 18 lbs since her therapies, less than 3 weeks ago. She has now begun a regular physiotherapy program and is gaining walking strength and balance. The recapitulation of the course of her disease (MS) within days, provides evidence that the in vitro requirement of cell pluripotency has correctly been identified with respect to adult cell source origin, time, and manipulation in culture.
The logic behind cell replacement therapy is that many or most neurodegenerative orders have a localized origin related to a specific area of the Central Nervous System. If treated selectively or super-selectively with the correct proportion of pluripotent cells using an effective protocol including method of delivery, and concentrations high enough to be considered clinical yet within the domain of safety, results would be clinically significant as in the case of Deb O’Connell.
This also seems to be the case in diseases such as MS, MSA, Parkinson’s disease and ALS among several others. In PD for example, strategies are aimed at dopaminergic cell replacement with implantation focused in the substantia nigra. In clinical trials there are some instances where these cells have survived for over 10 years, or the length of the study to date. While it is still too early to predict long-term outcomes for all of the MS patients who undergo the combination therapy protocol, there are results that can be used predicatively from a similar therapeutic study model that was established by Augusto Brazzini in his Clinical Study that followed Parkinson’s disease patients for a period of years. The Clinical Study, entitled “Intraarterial Autologous Implantation of Adult Stem Cells for Patie...”, has been ongoing since 2006. The study shows that neurological improvement in patients implanted with Mesenchymal Neuroprogenitor cells who recover 50-90% of their full function in the first 90 days begins to slow but progressively improves and maintains those improvements without the need for a second intervention. Furthermore, patients have seen clinical improvements only begin in a period from 3-9 months after first cell implantation.
For over a year other CCSVI Clinic patients have similarly benefited from the therapies, and each patient (who has not fallen outside of the inclusionary/exclusionary criteria either pre or post-operatively) is under case study at this time. Results to date have been consistent and reproduceable with no serious adverse events. We are aware of the value of long-term follow-up and that blind clinical trials have been the established method of determining both safety and efficacy. However where no model exists for the clinical study of cells unique to each patient, an adequate substitute would be a case-control approach. Although as in the case of testing for the efficacy of the ‘liberation therapy’ itself, this design has been much maligned, we believe that a rigorous case study can return measurable results in a more ethical design.
Deb O’Connell will be followed for the next 5 years in our study and updates will be made on her YouTube video through the informed consent process. For more information on the CCSVI Clinic Protocol you may contact the Clinic at info@ccsviclinic.ca, or call 888-468-1554.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby blossom » Tue Oct 02, 2012 9:39 pm

NOT TO TAKE AWAY FROM MILESAP'S THREAD BECAUSE I THINK WHAT HE POSTED IS REALLY GREAT TO KNOW.--THANKS MILESAP!
ALTHOUGH HOUSTON TO MY KNOWLEDGE ISN'T DOING WHAT INDIA IS "YET" IF THEY CAN GET THE GREENLIGHT I THINK ALL HELL WILL BREAK LOOSE IN THE USA AND THE WHAT IS NORM TO DRUG EVERYONE UP FOR WHAT THEY NAMED MS AND THESE AWFUL OTHER DISEASES THAT THE DRUG CO.'S HAVE HAD FULL REIN OVER FOR WAY TOO LONG JUST MIGHT NOT BE THE NORM ANY LONGER. COME ON--YES I WANT THINGS CHECKED OUT--YES WE NEED SOME SAFETY IN PLACE---BUT, COME ON NOW ISN'T IT A PRETTY LAME REASON THE FDA IS BUCKING THIS ""MY OWN STEM CELLS FROM MY OWN BODY SHOULD NOT BE CONSIDERED A DRUG?"" THEY'RE MINE AND NOBODY WHIPPED THEM UP IN A LAB AND TESTED THEM ON RATS. SINCE CCSVI AND DR.'S LIKE DR. SCLAFANI, DR. ROSA, DR. FLANAGAN, DR. AMIR AND MANY OTHER GREAT DR.'S HAVE GOTTEN INVOLVED AND THINGS ARE FALLING INTO PLACE MORE AND MORE--THEN TO HAVE THE OPTION TO HAVE THE HEALING POWER OF OUR OWN STEM CELLS TO ENHANCE THESE GOOD DR.'S WORK--YET THEY "THE FDA" "OR WHOEVER"ARE SO DESPARTLY GRASPING AT LOOSE ENDS TO STOP ALL THIS SO ALL OF US CAN HAVE INS. AND A MEANS TO BE TREATED ONCE FDA APPROVED--"MY STEM CELLS A DRUG?" COME ON -- SEEMS TO ME THOSE THAT HAVE BENEFITED FROM ALL US ARE HAVING A HARD TIME GIVEING UP THE GOOSE THAT LAID THE GOLDEN EGG. HERE'S WHERE IT STANDS RIGHT NOW---

Celltex To Initiate New Clinical Program As It Responds To FDA Letter
— FDA claims making identical copies of a person's own stem cells is manufacturing a drug -
By Celltex Therapeutics Corp.

Celltex Therapeutics Corp.
Last modified: 2012-10-01T20:20:30Z
Published: Monday, Oct. 1, 2012 - 1:20 pm
Copyright 2012 . All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
HOUSTON, Oct. 1, 2012 -- /PRNewswire/ -- Celltex Therapeutics Corp. announced today that it has received a letter, dated Sept. 24, 2012, from the U.S. Food and Drug Administration. The letter stated the agency's opinion that the process Celltex uses to multiply adult stem cells is subject to FDA regulation as biological drug manufacturing. The issue is a key one as stem cell therapy for patient care outside of an academic institution is a new frontier, yet there are a variety of technologies being used throughout the United States, often creating complex legal and regulatory questions.
David Eller, CEO and President of Celltex, stated:
Celltex makes identical copies of an individual's own stem cells and therefore should not be subject to FDA regulation as drugs. However, the FDA said our process causes the cells to be considered biological drugs and thus is subject to those regulations. We respectfully but firmly disagree with the FDA and intend to contest the agency's opinion within its administrative procedures. We are considering all options as we work with the agency toward a resolution.
FDA's letter also repeats its earlier observations from an April inspection of Celltex's laboratory. While Celltex provided detailed responses in April, May, June, July and August, now FDA tells us it needs more information. We will answer FDA's questions in whatever detail the agency requests."
We will meet FDA's requirements, no matter how high the hurdles may be, to ensure access to this technology. Celltex remains fully committed to advance the most promising new field in human health in decades — regenerative medicine. We also remain committed to doing so safely, and we will continue to comply with federal and state agency requirements.
As we work with the FDA, Celltex will continue to make advances on the frontier of regenerative medicine, and we expect to have several significant announcements in the coming weeks on these matters:
Celltex is preparing Investigational New Drug (IND) clinical trials focused on the effectiveness of adult autologous stem cells for specific conditions, such as multiple sclerosis, osteoarthritis and macular degeneration.
Enrollment in Celltex's current clinical trials has reached the goal of 200 patients who received their own stem cells from their physician-investigators. Data collection and analysis have commenced, and results are expected to be published in 2013. This will represent the largest, and potentially the most important, adult autologous mesenchymal stem cell study conducted in the United States.
"Celltex is committed to developing the promise of regenerative medicine into a reality for doctors and their patients," Mr. Eller said. "We sponsor clinical trials to better understand the therapeutic impact and monitor the safety of adult stem cell therapy, and we are confident that our research will help implement effective treatments for patients suffering from a variety of medical conditions."
For more information on Celltex Therapeutics Corporation and its staff please visit http://www.CelltexBank.com.
About Celltex
Celltex Therapeutics Corporation is a leader in providing services for the rapidly expanding field of regenerative medicine. Specifically, Celltex purifies, multiplies, and stores adult adipose-derived mesenchymal stem cells and rigorously follows the standards of good manufacturing practices for human cell laboratories. Celltex's laboratory currently holds more than fourteen patents protecting methodology and quality control. The Celltex process ensures extracted adult stem cells are separated, multiplied and stored without any genetic alteration or exposure to stimulants to alter the cells' natural multiplication ability. Celltex is currently researching new methods and technology for banking and stem cell treatment therapies to further the field of regenerative medicine and document the therapeutic impact of adult stem cell therapies on various medical conditions.
For more information contact: Celltex at 713.590.1000 For media inquiries contact: 512.763.2656
SOURCE Celltex Therapeutics Corp

Read more here: http://www.sacbee.com/2012/10/01/487153 ... rylink=cpy
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby 1eye » Thu Oct 04, 2012 3:40 pm

Sounds to me like the FDA stands for Fools and Drug Addictions. If ever anything was designed to make a right-thinking individual barf, this is it.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby blossom » Thu Oct 04, 2012 4:47 pm

1eye, that's very good definition.
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby daniel » Wed May 29, 2013 10:44 am

There was another update video for Deb O'Connell back in December 2012:

https://www.youtube.com/watch?v=52bKBBIdaco
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Re: Another Stem Cell and CCSVI success story was 9.5 EDSS s

Postby 1eye » Thu May 30, 2013 5:59 pm

Well, today I went in for my first neurology appointment since January of 2010. Reason being, a local neurologist was willing to see me. Of course she gave the game away early, by referring to a very complete history of my case, which told her, before I mentioned it, of my ill-fated 2 year involvement with BioMS and MBP8279. She had done her homework, as had the Ottawa Hospital and a cast of the usual suspects.

I think by the way that I have fallen out of favour with the chemo lads over at Ottawa Hospital because I purposely missed the "radiology" appointment where they would have basically given me a second radio-cardiogram so they could measure the damage either mitoxantrone or MBP8298 had done to my heart, after the resulting heart attack and handy-dandy stent-work on my chest that the good folks over at the Heart Institute had done. I am not sure I would have benefited, from a long test with radioactive dye. What would they do, put me on a heart transplant list? I don't think so. I already knew I was "too old" to get chemo-ablation, though I was not too worried about it, since I know they have improved the "protocol" a lot since they lost that patient. At least he had not died in vain.

But as soon as I mentioned that my new GP had been excited about the autologous stem cell results, and recommended that treatment over the CCSVI re-do I was still considering, my new neurologist agreed that I was way "too old" for that treatment. There had been that fatality, a few years back, of an ablation patient, you see.

Fatalities can apparently serve many differing arguments, because even Dr. Freedman had said something in the press recently about it being "safer now". I think that was why my GP had gotten interested.

So the latest encounter with neurology resulted only in a new symptomatic drug offering. She said that the ablation treatment was only for younger patients, who are definitely "relapsing-remitting" but have very aggressive course. I have one of those, and I consider my 2010 CCSVI treatment to have given me a definite "remission", but I guess I am too old, at 58.

I have survived a lot -- heart attack, 3 stents, 80 zillion blood tests, many many injections of gadolinium, umpteen MRIs, including a very early one of my neck 8 years before my "MS" diagnosis, 2 years of MBP8279 "un-fusions" (that is, they were really placebo), and 3 mitoxantrone infusions. During them, the local "MS" powers-that-be had phoned my druggist and cancelled my copaxone prescription, unilaterally, even though it had been verbally OK'ed by Dr. Atkins, my chemo doctor. A short while later (after I had stopped using both) a paper was published, claiming a "synergy" between mitoxantrone and copaxone. Surprise!

So I expect, barring any deus-ex-machina kinds of things, I will die with this. It's OK, anyway. I really miss walking, guitar, driving, and my left hand can't even do much piano-noodling anymore. But I'm sure you guys are on the right track, my immediate family history could be instructive to anyone really interested, and future "MS" patients will have brighter prospects than I had. I hope the Indians blow those alchemists right out of the water.

I am proud to have had Morgenthaler as a contemporary.
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