OCT should be a measurement in CCSVI trials

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

OCT should be a measurement in CCSVI trials

Postby Cece » Wed Oct 03, 2012 8:27 am

http://www.medpagetoday.com/clinical-co ... id=5517461
Retinal thickness as measured with a high-tech ocular scanner in multiple sclerosis (MS) patients correlated significantly with the volumes of certain brain structures, researchers said.
Overall, Saidha and colleagues concluded, "although our observations require verification, they provide support for the potential use of OCT [optical coherence tomography] as an adjunctive outcome measure in MS clinical trials."

If OCT is able to substitute as a measurement of brain atrophy, then it may well be a measurement that responds to CCSVI treatment. I don't think it's very expensive either. There have been anecdotal reports, mainly by Cheer, of improvement in brain atrophy after CCSVI treatment, and it's logical to think that if the improved blood flow is positive in many ways for brain health, that this will have an impact on atrophy.
Associations between retinal thickness measurements and brain substructure volumes were different for MS patients' eyes versus eyes without a history of optic neuritis.

Almost none of the correlations were significant in the optic neuritis eyes, whereas one or more retinal thickness measurements were significantly (P<0.05) correlated with volumes of cortical gray matter, normal-appearing white matter, caudate, thalamus, and MS-type lesions.

Huh. A trial of CCSVI using OCT as an outcome measurement would have to exclude eyes with a history of optic neuritis.
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