endothelial cells stimulate neural stem cells

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

endothelial cells stimulate neural stem cells

Postby Cece » Wed Oct 03, 2012 1:20 pm

http://www.sciencemag.org/content/304/5675/1338.short
Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells
Qin Shen1, Susan K. Goderie1, Li Jin1, Nithin Karanth1, Yu Sun1, Natalia Abramova1, Peter Vincent2, Kevin Pumiglia3 and Sally Temple1,*

Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes 1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.

Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotypes of the nervous system. Stem cells are characterized by their capability to differentiate into multiple cell types via exogenous stimuli from their environment.[1] They undergo symmetric cell division into two daughter cells, one non-specialized and one specialized. NSCs primarily differentiate into neurons, astrocytes, and oligodendrocytes.[2]
http://en.wikipedia.org/wiki/Neural_stem_cell

If CCSVI affects the endothelium of the capillaries of the brain, then it affects the neural stem cells and their ability to repair or replace damaged brain cells.
As much as we can, we need to do the things that benefit the endothelium: nutrition, exercise, laughter, supplements, improved blood flow.
Cece
Family Elder
 
Posts: 8990
Joined: Mon Jan 04, 2010 4:00 pm

Advertisement

Re: endothelial cells stimulate neural stem cells

Postby 1eye » Thu Oct 04, 2012 7:21 am

Cece wrote:If CCSVI affects the endothelium of the capillaries of the brain, then it affects the neural stem cells and their ability to repair or replace damaged brain cells.
If endothelial cells promote the growth of neurons, there can be no doubt that CCSVI, if not directly causing "MS", is implicit in perpetuating it, by preventing this promotion.
Cece wrote:As much as we can, we need to do the things that benefit the endothelium: nutrition, exercise, laughter, supplements, improved blood flow.
The laughter part is getting harder and harder to come by. In fact, if it is necessary to treat "MS", certain people can be seen to be perpetuating "MS", by doing their utmost to prevent mirth.
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
User avatar
1eye
Family Elder
 
Posts: 2876
Joined: Wed Mar 17, 2010 4:00 pm
Location: Kanata, Ontario, Canada

Re: endothelial cells stimulate neural stem cells

Postby Cece » Thu Oct 04, 2012 8:44 am

1eye wrote:
Cece wrote:If CCSVI affects the endothelium of the capillaries of the brain, then it affects the neural stem cells and their ability to repair or replace damaged brain cells.
If endothelial cells promote the growth of neurons, there can be no doubt that CCSVI, if not directly causing "MS", is implicit in perpetuating it, by preventing this promotion.

Exactly. Neural stem cells, and the endothelial cells that surround them, are essential in the response to ongoing damage. MS is a condition of chronic ongoing damage.
1eye wrote:
Cece wrote:As much as we can, we need to do the things that benefit the endothelium: nutrition, exercise, laughter, supplements, improved blood flow.
The laughter part is getting harder and harder to come by. In fact, if it is necessary to treat "MS", certain people can be seen to be perpetuating "MS", by doing their utmost to prevent mirth.

I don't like that Dr. Trabbolouse is in charge of the Canadian CCSVI trial. I don't see why this is not being led by a vascular specialist. The condition being treated is vascular.

We need Donnchadh with the latest satire and maybe a racing mouse. Dr. Trap A Louse.
Cece
Family Elder
 
Posts: 8990
Joined: Mon Jan 04, 2010 4:00 pm

Re: endothelial cells stimulate neural stem cells

Postby 1eye » Thu Oct 04, 2012 11:15 am

I think it's pronounced more like "trouble Lucy".
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
User avatar
1eye
Family Elder
 
Posts: 2876
Joined: Wed Mar 17, 2010 4:00 pm
Location: Kanata, Ontario, Canada

Re: endothelial cells stimulate neural stem cells

Postby cheerleader » Fri Oct 05, 2012 8:27 am

Nice paper, Cece---
those endothelial cells are responsible for a lot, interesting to see the connection to neural proginator cells....you're right, it's wise to keep them healthy.
Dr. Cooke's quote is "you are as old as your endothelium." And there's peer-reviewed research on how to help keep these cells functioning. Even the Livestrong site has it now...
http://www.livestrong.com/article/55614 ... alth-diet/
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
User avatar
cheerleader
Family Elder
 
Posts: 5015
Joined: Mon Sep 10, 2007 3:00 pm
Location: southern California


Return to Chronic Cerebrospinal Venous Insufficiency (CCSVI)

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users

cron