drug works for retinal vein occlusion

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

drug works for retinal vein occlusion

Postby Cece » Thu Nov 15, 2012 8:23 am

http://www.medpagetoday.com/MeetingCove ... id=5517461

Could an "anti-vascular endothelial growth factor (VEGF) drug" work in CCSVI or in CCSVI patients with occluded veins? What does an "anti-vascular endothelial growth factor (VEGF) drug" do?
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Re: drug works for retinal vein occlusion

Postby DougL » Thu Nov 15, 2012 10:37 am

WIKI

VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.

When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body.


Drugs such as bevacizumab can inhibit VEGF and control or slow those diseases.
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Re: drug works for retinal vein occlusion

Postby Cece » Thu Nov 15, 2012 10:48 am

So anti-VEGF would slow down the development of new blood vessels. Not the right direction, I would think. Thanks DougL.
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