MarkW wrote:Hello Anonymoose and anyone considering Clonidine,
Please do not use Clonidine as an angioplasty alternative. Get the venoplasty done by a leading practitioner (diagnosis with CV +IVUS) before considering Clonidine and then under medical supervision. I was an industrial pharmacist and my industry loves long term use of medicine. But CCSVI syndrome produces a physical problem (stenoses) and needs a physical treatment first.
I do believe you are correct.
Given that reduced perfusion can cause hpa-axis dysregulation, I now believe that CCSVI *can* cause MS, the whole shaboodle. I'm no longer worried about Cece and those who have found near complete recovery through PTA. I think they are cured (so long as veins stay open). Yay!
I'm pretty sure I don't have CCSVI. I don't have any of the trademark symptoms and I've had a lifetime of high stress levels to botch my hpa-axis w/o any other contributing factors. Clonidine is doing wonders for me and I'm starting to suspect my hippocampus is recovering from it's insensitivity to cortisol. The clonidine is starting to make me feel a bit sleepy, which to me indicates that my hpa-axis might be becoming less active, warranting less suppression. So, maybe taking clonidine isn't a forever thing for those w/o ccsvi.
For those who haven't found success through PTA (or chiro/dental options, I keep forgetting about those), CCSVI or not, I think clonidine is a great and relatively safe option. It's ability to tame MS symptoms and make life more comfortable and normal alone should make it worth a try. Of course, thus far, it's a study of one. I can only hope it would have the same results for others. Luckily, just like there are IRs willing to perform PTA, there are doctors willing to prescribe Clonidine off label. If you (a general "you") think this makes sense, you don't have to wait for the MS doctors to come to this conclusion. Just try it. <shrug>
Btw, that study about hypoperfusion and CA1 pyramidal neuron activity in the hippocampus...that's the CCSVI tie-in to MS. It's (almost) proof that CCSVI can cause the MS cascade...well, once they realize that hpa-axis dysregulation is a key factor in the development and progression of MS. Oh boy. This could take a while.