New Paper:Low vit and carotenoid lvls are related to lesions

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: New Paper:Low vit and carotenoid lvls are related to les

Postby jimmylegs » Fri May 24, 2013 5:35 pm

i haven't heard anything negative about toxicity from dietary vit e, period. afaik it's purely supplements that require us to worry about high alpha low gamma. b/c they have traditionally been made from synthetics and in unnatural ratios.
here's my post from the other day re dietary sources of vit e complex regimens-f22/topic2489-570.html#p208785
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Re: New Paper:Low vit and carotenoid lvls are related to les

Postby CureOrBust » Fri May 24, 2013 7:18 pm

I tried a search of toxicity, and the "worst" I could find was http://www.tribulusterrestrisextract.com/vitamine.html (which was not gamma specific)
Vitamin E overdose, symptoms, side effects
Digestive disturbances are common with vitamin E overdose. Very high dosages of vitamin E, such as 1,000 units or more, can lead to an increase in bleeding tendency, tiredness, weakness, headache, nausea, and possibly impaired immune function. The symptoms of vitamin E overdose go away relatively quickly after stopping the supplement. It is nearly impossible to have a vitamin E overdose from food alone.

Are you taking too much vitamin E? Oerdose and toxicity
Researchers at Johns Hopkins University in Baltimore pooled data from 19 trials of vitamin E supplementation. These included nearly 136,000 subjects who were randomly assigned to take vitamin E or placebo capsules and were followed for more than a year. Overall, vitamin E supplementation did not affect mortality rates. However, the trials testing doses of 400 IU daily or higher showed 39 more deaths occurred per 10,000 people taking high-dose vitamin E than among the same number of people taking a placebo. For low doses of vitamin E -- less than 150 IU daily -- mortality rates were slightly decreased.


I did find ONE persons review of a Vit E tablet at an online store that said "This was too strong for daily use and gave me headache, brainfog, irritation, etc."
Code: Select all
Mixed Tocopherol Complex
Vitamin E (d-alpha tocopherol)   50 IU (34 mg)   167%
Gamma-tocopherol                       300 mg   *
Other tocopherols (d-beta & d-delta)   100 mg   *
* Daily Value not established.


The following links were just things I came across which others may find interesting on vit E, but your own searches may be better. 8)
Not MS specific, but gives a broad overview of Vit E, including the content in some foods
http://lpi.oregonstate.edu/infocenter/v ... /vitaminE/
http://www.exrx.net/Nutrition/Antioxida ... aminE.html

And some explanation of the diff between the two forms
http://resources.purematters.com/herbs- ... tocopherol
http://www.helium.com/items/1355259-alp ... tocopherol
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Re: New Paper:Low vit and carotenoid lvls are related to les

Postby jimmylegs » Fri May 24, 2013 7:51 pm

i think it depends as well how long you take it for and how badly your body needs it (or doesn't).

i have had difficulties testing my own vit e status (not covered and not always easy to find a lab that will run the test) but when i was dxd my dietary intake was negligible and i did the klenner protocol vit e dose to the tune of 2400 IU per day of plain old alpha tocopherol with no ill effects. as soon as i learned about e8 complex i switched anyway. but it's still best to keep your vit e intakes from food high. we're not adapted well to nutrients in isolation, and we don't tend to know as much as we should about interactions when we take supplements. a nutrient dense whole food diet should be the foundation.

here is the specific study in which the data tables demonstrate serum alpha tocopherol on the rise and the gamma tocopherol decreasing, during the study period in which participants were given 400 IU per day of a synthetic preparation of alpha tocopherol. hence the conclusion states specifically "Selenium or vitamin E, alone or in combination at the doses and formulations used, did not prevent prostate cancer in this population of relatively healthy men." the key words being at the doses and formulations used.

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other CancersThe Selenium and Vitamin E Cancer Prevention Trial (SELECT)
http://jama.jamanetwork.com/article.asp ... eid=183163
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