Abstracts for the 2013 AAN Annual Meeting Scientific Program are now available to view online.
[P01.085] Evaluation of Cerebral Hemodynamics of Patients with Chronic Migraine: Effects of the Botulinum Neurotoxin-A
Hakan Akgun, Ankara, Turkey, Serdar Tasdemir, Ankara, Turkey, Mehmet Yucel, Istanbul, Turkey, Oguzhan Oz, Ankara, Turkey, Umit Ulas, Ankara, Turkey, Seref Demirkaya, Ankara, Turkey, Yasar Kutukcu, Ankara, Turkey
OBJECTIVE: Migraine is a neurovascular disorder. Change in the diameter of intracranial arteries is thought to be an important underlying mechanism in migraine pathophysiology. Transcranial-Doppler-Ultrasound (TCD) is a non-invasive method to evaluate intracranial vascular system. Recent studies showed that botulinum neurotoxin-A (BoNTA) is an effective treatment choice in migraine headache. BACKGROUND: We aimed to evaluate the changes in middle cerebral artery (MCA) and posterior cerebral artery (PCA) in terms of Mean Blood Flow Velocity, Breath-Holding-Index (BHI) and pulsatility index (PI) in patients with chronic migraiene before and after treatment with BoNTA by using TCD. DESIGN/METHODS: The study included 25 patients with chronic migraine. 12 patients were treated with high-dose (100 IU) BoNTA and 13 patients were treated with low-dose BoNTA (50 IU). BoNT was injected to facial, scalp and neck muscles. Mean blood flow velocity, BHI and PI were measured before and 7 days after BoNTA injection in MCA and PCA bilaterally in both groups. We compared the pre-treatment and post-treatment values. We also evaluated the Visual Analogue Scale (VAS) scores in both groups before and after-treatment. RESULTS: Pulsatility index was significantly decreased in MCA (before treatment PI=0,74±0,13, after treatment PI=0,69±0,10) (p=0.024) and insignificantly changed in PCA after treatment in high-dose group (p>0.05). Differences in Mean blood flow velocity and BHI were insignificant in both groups in both arteries (p>0.05). VAS scores significantly decreased after treatment in both groups (p<0.001). CONCLUSIONS: The PI is a well known indicator of peripheral vascular resistance. Our results suggest that BoNTA treatment may be effective by reducing the resistance in intracranial vascular beds in patients with chronic-migraine.
Category - Headache: Therapeutics
Could this help pwCCSVI as well? It's botox delivered to the facial, scalp and neck muscles. This led to a reduction in intracranial vascular resistance in migraine patients.
http://www.abstracts2view.com/aan/view. ... 3L_P01.085