vesta wrote:Hi Anonymoose:
At one point you were recommending clonidine. And then I think you stopped taking it. Why?
Anonymoose wrote:Hey NZer,
Regarding the hpa axis, I think the study you linked was a bit misleading. Yes, we need crh and its cascading hormones to be healthy...hence worse progression with greatly impaired hypothalamus. However, I think the constantly activated hpa axis is detrimental to a number of ms related conditions (endothelial health, bbb, peripheral nerves, muscle tension/blood flow, etc).
Here's a more current study that sees hpa axis dysregulation in MS in a more negative light.
http://www.sciencedirect.com/science/ar ... 7213000438
I'm pretty sure the crh is being released in response to cytokines. I'm experiencing the same improvements by inhibiting cytokines associated with MS damage that I did when I was just inhibiting ACTH (step after crh). Fenofibrate also affects lipid metabolism and d3 production so those might be contributing factors too. The difference between feno and the interferons in respect to immunomodulation is that feno, unlike interferons, doesn't cause hpa axis hikes and depressions...which I believe might be the cause of negative reactions and what I observe to be faster decline in those taking interferons (totally unscientific observation).
I don't think we need cpn to mess up our endothelium. Our chronically activated hpa axis can do that on its own. It could be that if there is cpn, it and our immune response to it are crossing the bbb because our hormones are making it weak and permeable. Just my opinion.. Though I do wonder what is triggering the cytokines if we don't currently have an active breach of bbb.
Anonymoose wrote:vesta wrote:Hi Anonymoose:
At one point you were recommending clonidine. And then I think you stopped taking it. Why?
Hi Vesta,
After about two and a half months on clonidine my blood pressure suddenly got really low and stayed low on the tiniest of doses. I quit and it came back up after about 22 hours. In the month or so between clonidine and fenofibrate, I took clonidine a few times to ease returning neck tension. It still worked and didn't lower my blood pressure if I only took it for a day or two (didn't try longer).
I tried to unrecommend it in multiple threads for people with low or normal blood pressure but I must not have done a very good job.
NZer1 wrote:Moose, has anyone worked out why you are unwell?
Calling or labelling a disease is only a minor part of wellness return of course and I wonder what the disease process is that you are combating?
Nigel
NZer1 wrote:Hi 'Moose,
the treatment is rolling along like a steam roller as predicted and time doesn't stand still!
Don't know how many anniversaries there will be on the Protocol yet, 22nd Sept I began the official pill popping process, had been on the NAC treatment since mid Feb as a trial.
What tests have you had regarding the possible causes and effects of your symptoms?
Bloods for indications?
MRI's of Spine and brain?
MRI's done over time/years?
CCSVI tests Doppler or treatments IVUS, PTA?
CFS flow tests?
Spinal alignment assessment?
Personal Health History study for interconnected outcomes?
What methods/treatment are you using at present?
Nigel
Anonymoose wrote:NZer1 wrote:Hi 'Moose,
the treatment is rolling along like a steam roller as predicted and time doesn't stand still!
Don't know how many anniversaries there will be on the Protocol yet, 22nd Sept I began the official pill popping process, had been on the NAC treatment since mid Feb as a trial.
What tests have you had regarding the possible causes and effects of your symptoms?
Bloods for indications?
MRI's of Spine and brain?
MRI's done over time/years?
CCSVI tests Doppler or treatments IVUS, PTA?
CFS flow tests?
Spinal alignment assessment?
Personal Health History study for interconnected outcomes?
What methods/treatment are you using at present?
Nigel
Nzer,
I don't know how you manage to keep your brain working on CAP. I thought I was doing great on it...now I can't even remember most of those months! I hope it's over for you sooner rather than later.
Aside from my initial MRI in August, I don't have much other data that I find to be super useful. Ive done the usual nutrients, cortisol, cholesterol and liver tests. I'm starting to think about that csf flow and ao though.
Right now I'm just taking 96mg/day of fenofibrate, a multi, and 400mg magnesium.
A random oddity, since I've been thinking about it all day...maybe you can figure it out as it is CAP related. Since around the time of my first flare (janish 2010, whever the olympics were) I've had a small amount of clear fluid leaking out my nose (after I tip my head down and lift) and ears (when I sleep). It stopped whilst I was on CAP and just started again this week. With all this csf pressure talk, I'm wondering if it isn't csf leaking. Any idea about how CAP might stop that? (Clonidine would have reduced csf pressure and I was on that about a week after I completely stopped CAP). Also found something about vitamin d being something to avoid if you have iih. It made me think of that video you posted in the d3 thread a while ago. I need to dig into it more and will post if its worth it...tomorrow.
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