Obesity raises MS risk in girls 4X

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Obesity raises MS risk in girls 4X

Postby cheerleader » Sat Jun 22, 2013 7:54 am

Extremely obese girls have 4x the risk of developing MS.
It is essential that researchers look at the connection of cardiovascular health, endothelial function and MS.

"The overall message is that there are an increasing number of diseases associated with obesity and particularly early obesity and that it's an important risk factor to try to mitigate. It is something you can do something about," Chitnis says.

According to the Centers for Disease Control and Prevention, over the last 30 years childhood obesity has doubled in children and tripled in teenagers. In 2010, more than a third of all children and teens were overweight or obese.

At Children's Hospital of Alabama, pediatric neurologist Dr. Jayne Ness has seen more than 100 pediatric MS patients, predominantly girls, whose average age at onset is 13. Ness told CNN she has noticed a rise in obesity in their MS patients, kids who at the time of diagnosis are obese.

http://thechart.blogs.cnn.com/2013/01/3 ... udy-finds/

Obviously, it is not just obese girls developing MS...Jeff was a fit man. But this is another sign pointing to the link between the heart and the brain. And it's something we can control.

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Obesity raises MS risk in girls 4X

Postby cheerleader » Sat Jun 22, 2013 8:05 am

A proposed mechnism?
In the CCSVI paradigm, obesity causes jugular valve insufficiency in those with idiopathic intracranial hypertension---related to intra-abdominal pressure. Weight reduction reduces transverse sinus stenosis and venous insufficiency.

http://www.ncbi.nlm.nih.gov/pubmed/19252781
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: Obesity raises MS risk in girls 4X

Postby Cece » Sat Jun 22, 2013 1:04 pm

The association (of obesity and MS) doesn't necessarily mean causation. Fatigue and impaired ability to exercise because of heat intolerance and MS fatigue could be the cause of the weight gain especially since we live in a fattening culture. (If we eat like everyone else but move less because of MS, we will gain weight.)

But if it is causative, I would go with the intra-abdominal pressure theory too.
I would have thought the higher levels of estrogen in obese girls would have had a protective effect; doesn't being on birth control have a protective effect? So if the obesity is contributing to the onset of MS, there would be an effect negative enough that it overcomes the positive effect of increased estrogen.
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