Multiple sclerosis shrinks intralesional, and enlarges extra

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Multiple sclerosis shrinks intralesional, and enlarges extra

Postby frodo » Mon Jun 24, 2013 3:28 pm

I don't know if this is important, therefore I post it just in case anybody finds it useful.

Multiple sclerosis shrinks intralesional, and enlarges extralesional, brain parenchymal veins

http://www.ncbi.nlm.nih.gov/pubmed/23255828

Abstract
OBJECTIVES:
Many multiple sclerosis (MS) lesions develop around small veins that are surrounded by perivenular inflammatory cells, but whether veins in the brains of people with MS are smaller or larger than similar veins in healthy volunteers or people with other neurologic diseases remains unknown. This question can be addressed by high-resolution, high-field-strength MRI.
METHODS:
In a cross-sectional study performed on a standard 3 T clinical scanner, we acquired whole-brain T2*-weighted images with 0.55 mm isotropic voxels and reconstructed the courses of deep and superficial veins within the white matter. We compared the apparent diameters of intralesional and perilesional veins to those of extralesional MS veins, veins in healthy volunteers, and veins in individuals with other neurologic diseases.
RESULTS:
We studied veins in 19 MS cases, 9 healthy volunteers, and 8 individuals with other neurologic diseases, analyzing a total of 349 veins. The mean diameter of intralesional veins (0.76 ± 0.14 mm) was smaller than that of perilesional (1.18 ± 0.13 mm; p < 0.001) and extralesional (1.13 ± 0.14 mm; p < 0.001) veins, regardless of lesion size and location. Perilesional and extralesional MS veins were larger than non-MS veins (0.94 ± 0.14 mm; p < 0.001), and intralesional MS veins were smaller (p < 0.001).
CONCLUSIONS:
The small apparent size of intralesional MS veins may reflect compression by the perivascular inflammatory cuff within active lesions or hardening of the vascular wall in chronic lesions. The finding that extralesional veins are larger than similar veins in non-MS lesions may result from diffuse disease-related processes.
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Re: Multiple sclerosis shrinks intralesional, and enlarges e

Postby 1eye » Fri Jun 28, 2013 11:15 am

It seems intralesional veins are affected by "MS". I have seen implications lesions are not always peri-venular. Is this so? Are "MS" lesions ever found around arteries? :?:

Is there arterial as well as venous hypertension? If there is generalized venous hypertension I could believe all the veins except sclerotic ones were bigger, bigger than they should be. Perhaps the sclerosis serves to create a snapshot of the pre-lesion normal size of all the other veins.
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
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Re: Multiple sclerosis shrinks intralesional, and enlarges e

Postby frodo » Tue Jul 02, 2013 12:17 am

1eye wrote:It seems intralesional veins are affected by "MS". I have seen implications lesions are not always peri-venular. Is this so? Are "MS" lesions ever found around arteries? :?:

Is there arterial as well as venous hypertension? If there is generalized venous hypertension I could believe all the veins except sclerotic ones were bigger, bigger than they should be. Perhaps the sclerosis serves to create a snapshot of the pre-lesion normal size of all the other veins.


It is surprising the lack of information about these questions. If you write in google "MS immune system" thousands of pages explain the subject, but if you write "MS lesions" you get nothing interesting.
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