June 2013 research on EAE hypoxia

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June 2013 research on EAE hypoxia

Postby Cece » Mon Jul 08, 2013 9:50 am

http://www.ncbi.nlm.nih.gov/pubmed/23810780#

Wayne State University presents research on vascular hypoxia in EAE. Exposure to mild chronic low oxygen was good, not bad, for EAE in mice. Dr. Haacke is not among the authors but he is also at Wayne State University. This study was a 'preclinical study' to test the hypothesis that "restoration of microvascular angiodynamics would augment tissue plasticity mitigating the extent of secondary injury and sparing cognitive decline in patients with MS."
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Re: June 2013 research on EAE hypoxia

Postby 1eye » Mon Jul 08, 2013 10:06 am

I know it has no bearing, but I have always wondered how my wife got away with unconsciously covering her head with sheets for a large part of the night. She must be part mouse :-) .
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Re: June 2013 research on EAE hypoxia

Postby cheerleader » Mon Jul 08, 2013 10:12 am

Dr. Haacke does not have many fans in the neurology dept at Wayne State
Remember the wrath of Khan? He even used science fiction references in this editorial :)
http://jnnp.bmj.com/content/82/4/355

What's interesting about this study is how it kinda PROVES that EAE is not an appropriate model for MS.
Hypoxia for rats with EAE is good, but not for humans with MS.
We already know that MS lesions show hypoxic stress--
http://www.ncbi.nlm.nih.gov/pubmed/12764056
http://www.ncbi.nlm.nih.gov/pubmed/12559509

Pertussis toxin, used in most EAE models, might be what's responsible for the protective result of hypoxia....
http://www.ncbi.nlm.nih.gov/pubmed/8458024

this is all way above my paygrade, but it looks like more proof that EAE just isn't MS.
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Re: June 2013 research on EAE hypoxia

Postby Cece » Mon Jul 08, 2013 10:20 am

Yeah EAE is definitely not MS.
In ischemia, mild hypoxia is good for prepping neurons for a larger event and in mitigating the impact of a larger ischemic event, so in that sense mild hypoxia is 'good' for ischemia too.
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Re: June 2013 research on EAE hypoxia

Postby cheerleader » Mon Jul 08, 2013 11:59 am

There are plenty of models in humans that show how diffuse cerebral hypoxic injury leads to white matter degredation and neurodegeneration. If MS/CCSVI creates diffuse cerebral hypoxia, you don't need rats with pertussis to model it. We can see what happens in adults with Delayed Post-Hypoxic Leukoencephalopathy

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835522/
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Re: June 2013 research on EAE hypoxia

Postby orion98665 » Mon Jul 08, 2013 3:58 pm

Hmmm, i thought this quote was interesting. i know this may or may not be related to CCSVI , but i find it interesting were following the EAE model of MS and yet they admit MS is unique to humans..!!

Quote:
Humans are the exclusive natural host for EBV, a finding that may explain why MS is unique to humans.

http://onlinelibrary.wiley.com/doi/10.1 ... 3/abstract


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Re: June 2013 research on EAE hypoxia

Postby Cece » Mon Jul 08, 2013 4:34 pm

It is concluded that the ultimate test to the hypothesis of MS and EBV is the development and application of an EBV vaccine, which is predicted to eradicate the disease.

That's another good one from that abstract.
EBV impacts the endothelium and has an affinity for collagen so I think EBV could be relevant to CCSVI.
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