frodo wrote:I think traffic increase around the world could explain the "MS epidemics"
CuriousRobot wrote:Car accidents aren't a one-way street [forgive the pun]; what about people getting hit by other automobiles? Or drunk drivers?
Also, how do we qualify this "trauma"?
Evidence that physical trauma can open the blood-brain barrier, exposing the central nervous system to peripheral immune factors, and that trauma can trigger an immune cascade of inflammatory cytokines, shows that it is biologically plausible for trauma (certain types of trauma, at least) to increase the risk of MS. Post mortem studies also suggest that lesions may preferentially form at sites of mechanical stress. However, evidence from clinical studies looking for associations between MS and trauma have not yet produced compelling evidence that trauma is a significant risk factor. Similarly, epidemiological evidence such as gender prevalence data does not support a strong role for trauma as an MS risk factor.
Shayk wrote:This document (although dated) is one of the best "summaries" I've come across re: trauma and MS. Thought it may be of interest to some.
Analysis of research into the role of trauma and stress in the etiology of multiple sclerosis 2007
All the best
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