http://www.medpagetoday.com/Neurology/M ... id=5517461
More than 50% venous narrowing according to venography was found in 74% of MS patients, 66% of siblings, and 70% of controls. When identified by reductions in venous blood flow, narrowing was present in 51% of patients, 45% of siblings, and 54% of controls.
This was using catheter venography, but not intravascular ultrasound. While not the gold standard when used without ivus, catheter venography should have been enough to capture a difference if the IR was experienced and if there is a difference there.
Remember the Fox study looking at cadavers? Dr. Fox of the Cleveland Clinic found equal amounts of vein wall stenosis in both MS patients and controls, but he found intraluminal abnormalities in much greater prevalence among the MS patients. These intraluminal abnormalities are the problem; for me personally, both my jugulars had bad valves within the veins that were seen on MRI, ultrasound, venogram and ivus. One possibility with Dr. Traboulousee's nonresults is that he is counting that vein wall stenosis, as Dr. Fox also observed, that is equally prevalent in both groups.
Dr. Traboulousee did take this into consideration when he looked with the external ultrasound:
Ultrasound studies disclosed no abnormalities in half the MS patients as well as in half of the non-MS participants. Rates of absent valves, asynchronous valves, immobile valves, and valves that did not close fully were also nearly identical in patients versus controls.
But it is inside-the-vein intravascular ultrasound (ivus) that is needed, and in the hands of someone who has learned to see with it.
We can't ignore evidence. We also need to make sure we are interpreting evidence correctly, and that the evidence is gathered by someone who can recognize a valvular stenosis if one is there. The talk of death knells is over-done. We just had the Sherbourne National CCSVI Society meeting with positive research from Dr. Beggs and from Dr. Haacke's lab. CCSVI remains controversial but we have yet to have had the right studies done.