Nzer1. I for the life if me can't figure out how this paper further describes CCSVI.
As we know EAE is not MS. We've had 50 years to prove this.
Here is the latest explanation for CCSVI. Dr Hubbard.
Here he explains his theory for how hypoperfusion in the brain kills the oligdendroytes, which are cells that make the myelin which starts the whole cascade we call MS.http://www.youtube.com/watch?v=iJF5VRKC ... dMXOViVCtw
Here are some cool slides from the presentation:
Auto immune theory Status
Oligodendrocyte apoptosis (death)
Hypoperfusion and CNS venous drainage
fMRI BOLD venous undershoot Study
Clinical Outcomes of Venoplasty Study
Conclusions and Recommendations
Slides on the work of John Prineas and Michael Barnett who proved that
Oligodendrocytes die first, white cell enter later
His slides showing the prefusion Pre and Post Venoplasty
Auto-immune theory is unproven
Immunosuppressant drugs are marginally effective and incredibly expensive
Oligodendrocyte damage may be primary and may be related to poor venous flow and hypoperfusion
Preliminary evidence of efficacy for venoplasty
Don't discontinue your DMD's
Double-blind studies are planned
But, study design is complex
MS-MRI plus MRV and MR perfusion (ask you docs for an MRV and MR perfusion report when your getting you MS check up)
If abnormal, consider venoplasty
Learn about what else you can do to be proactive, Google Scholar
Double-blind vs Double-Hope.