KIR4.1 and CCSVI response

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

KIR4.1 and CCSVI response

Postby frodo » Thu Jan 23, 2014 2:14 pm

In 2012 a german team identified an immunoglobin, anti-KIR4.1, in a subset of MS patients (47%, see https://www.ncbi.nlm.nih.gov/pubmed/227 ... t=Abstract). Recently another team has confirmed this situation (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759297/)

The situation looks very similar to what happened with Neuromyelitis optica and AntiAQP4. Maybe there are two different multiple sclerosis. And this is crucial to know the impact of CCSVI procedures and to analyse its prevalence.

It seems that antiKIR4.1 is found in blood serum, for around a 47% of the patients. This fixes quite well in some old reports, about 4 patterns of lesions in MS. There was one pattern (pattern II, around 40% of the cases) that was responsive to plasmapheresis while the others didn't (see http://www.docguide.com/multiple-sclero ... sented-aan and http://www.pnas.org/content/105/48/18889.full.pdf). The presence of Kir4.1 in blood serum matches in this behavior.

Of course, the cases in which the problem is in the blood serum are not expected to respond to CCSVI treatment. Therefore, it seems that testing the blood serum status can determine the response to CCSVI.

Is there anybody that knows about laboratories that can perform these kir4.1 tests?
Last edited by frodo on Wed Jan 29, 2014 5:45 am, edited 4 times in total.
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Re: KIR4.1 and CCSVI response

Postby frodo » Fri Jan 24, 2014 3:52 am

Replying to myself, it seems that they can be found online here:

http://www.antibodyresource.com/search/ ... nel-kir4.1
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Re: KIR4.1 and CCSVI response

Postby frodo » Fri Jan 31, 2014 3:09 am

And I have found another one:

http://www.alomone.com/p/anti-kir4.1/apc-035/67

I still think this should be checked before trying CCSVI !!!!
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