Endothelan discovery

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tzootsi
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Endothelan discovery

Post by tzootsi »

Not only can endothelin issues cause circulatory problems, but now it looks like myelin repair might also be a factor:


Protein may repair brain tissue damaged by Multiple Sclerosis(10/02/14)

Multiple Sclerosis is an autoimmune disease that affects the brain and spinal cord, destroying tissue and cells along the way. Previous research and practices have found that therapies can help with relapses of MS, but cannot help repair the tissue and cells that have been affected.

After MS has affected the body and caused cell damage, the brain produces new cells to repair the old ones. However, a majority of cases has shown that there are unknown factors that hinder the cells from completely repairing, thus creating a permanent loss. The brain inflammation caused by MS leads to the destruction of myelin, which is the fatty insulation for the axon nerve fibers in the brain, thus destroying brain cells. A molecule known as Endothelin-1 (ET-1) is known to inhibit the repair of the myelin.

Yesterday, Gallo and his team of researchers reported their findings in Neuron and cited the effectiveness of a certain protein that could help fully repair previously damaged cells. This protein, known as "ET-R antagonist PD142,893" can be used therapeutically to promote remyelination and effectively block ET-1 from inhibiting cell repair.

"We demonstrate that ET-1 drastically reduces the rate of remyelination," Gallo said. "ET-1 is potentially a therapeutic target to promote lesion repair in deymyelinated tissue. It could play a crucial role in preventing normal myelination in MS and in other demyelinating diseases," Gallo said
Cece
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Re: Endothelan discovery

Post by Cece »

yeah I find this really interesting

http://www.ncbi.nlm.nih.gov/pubmed/11315981
ET-1 levels in people with MS are 224% higher than healthy controls

http://www.ncbi.nlm.nih.gov/pubmed/23959559
Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation.
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cheerleader
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Re: Endothelan discovery

Post by cheerleader »

ET-1 is a sign of endothelial dysfunction.
It is a vasoconstrictor (meaning, it closes up blood vessels)
It is a PRO inflammatory peptide, and implicated in cardiovascular disease.
http://cardiovascres.oxfordjournals.org ... 6/1/8.full

We can only hope that researchers will start asking WHY MS and CARDIOVASCULAR disease have ET-1 in common.


It is a scientific fact that people who have strokes have higher levels of ET-1 in their plasma. Just like pwMS. Ischemic injury causes ET-1 levels to rise dramatically. http://stroke.ahajournals.org/content/2 ... 4.full.pdf

Sure, blocking ET-1 can be developed into a drug----but what about dealing with endothelial dysfunction here and now, today--with nutrition, exercise, UV/vitamin D, stress reduction, losing weight, smoking cessation, avoiding transfats and sugar, and increasing nitric oxide...
NO is known to inhibit the production of ET-1--today.

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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muse
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Re: Endothelan discovery

Post by muse »

Just google “Magnesium & ET-1” and you will be surprised what kind of paper are coming up. If you have no time feel free to have a quick look at my FB-page because this topic is kind of my hobby and that’s why I’ve collected information/papers regarding “Magnesium effects on cardiac system” etc..
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