I've discussed the findings of The Lesion Project with a number of neurologists, and most of them are a bit skeptical of the findings. They say that even if a patient displays only one type of lesion postmortem, that does not mean that their lesions didn't evolve through different stages over time.
The different patterns could well just be due to the age of the lesion. And there's been no new research on the different "lesion patterns" since then. Lucchinetti has moved on to look at loss of gray matter in MS.
Well, now Luchinetti is back with a new article!!! And heterogeneity is again a real posibility. The age of the lesion is not associated with its type.
On the other hand, it seems that the Kir4.1 connection is not so clear as it seemed.
It is not explained in the abstract how the tests were performed but these are not positive news. We will have to wait for additional studies to see how this fixes in the global picture. Other groups still consider kir4.1 a possibility.
http://www.ncbi.nlm.nih.gov/pubmed/24817862 (no abstract but available in the next link)
http://journal.frontiersin.org/Journal/ ... 00062/full