Patent to diagnose MS based on Kir4.1

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Patent to diagnose MS based on Kir4.1

Postby frodo » Wed Jun 25, 2014 12:09 pm

Maybe this is not very related to CCSVI, or maybe it is. In any case is worth to share it.

Means and methods for diagnosing and treating multiple sclerosis
US 20140080156 A1

http://www.google.com/patents/US20140080156

ABSTRACT

This invention relates to a peptide comprising or consisting of at least 8 consecutive amino acid residues of the sequence set forth in SEQ ID NO: 3, provided that said peptide does not consist of the sequence set forth in SEQ ID NO: 3, or a corresponding peptidomimetic, wherein said peptide or peptidomimetic binds to an anti-KIR4.1 antibody comprised in a sample from a patient, said patient having multiple sclerosis or a predisposition therefor, wherein preferably (i) said at least 8 consecutive amino acid residues are a subsequence of an extracellular domain of KIR4.1, said extracellular domain consisting of the sequence set forth in SEQ ID NO: 1 or 2; or (ii) said peptide comprises or consists of the sequence of SEQ ID NO: 1 or 2. The present invention furthermore relates to a method for diagnosing multiple sclerosis or a predisposition for multiple sclerosis in a subject, the method comprising determining the presence of an anti-KIR4.1 antibody in a sample obtained from said subject, wherein the presence of an anti-KIR4.1 antibody in said sample is indicative of multiple sclerosis or a predisposition for multiple sclerosis. Also provided are novel means and methods for the therapy of multiple sclerosis.
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Re: Patent to diagnose MS based on Kir4.1

Postby cheerleader » Wed Jun 25, 2014 5:15 pm

I wrote up a blog post on KIR4.1 and the big picture. Researchers have found KIR4.1 (a potassium channel protein important in myelination) antibodies are higher in plasma for pre-clinical MS patients, when compared to healthy controls. But it's not all people with MS, only about half. But why? Where else do we see this happen?
There is a connection to cerebral edema and hydrocephalus--- and yes, this could be related to slowed venous drainage due to CCSVI.
more here:
http://ccsviinms.blogspot.com/2014/02/k ... cture.html

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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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