Impaired Blood Flow in Diabetic Brain Tied to Cognitive Prob

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.
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Cece
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Impaired Blood Flow in Diabetic Brain Tied to Cognitive Prob

Post by Cece »

http://www.medpagetoday.com/Neurology/G ... g454846d0r

Thought this was interesting and relevant to the discussion here.
"These correlations suggest that inflammation has a critical role in the degradation of cerebral vasoregulation in the milieu of chronic hyperglycemia regardless of glycemic control," they added.
Inflammation plus starved neurons equals cognitive decline
They said their findings also suggest that endothelial problems may develop early in the course of hyperglycemic damage, before any structural changes occur -- implying that early detection and monitoring of cerebral blood flow regulation may predict the acceleration of cognitive decline in patients with type 2 diabetes.
"Early detection and monitoring of blood flow regulation may be an important predictor of accelerated changes in cognitive and decision-making skills," Novak said in the statement.
If this can be monitored in diabetics, it can be monitored in MS patients.
Diminished vasoreactivity can lead to impaired cerebral blood flow to neurons, the researchers explained, potentially leading to impairments in cognitive function.
If diminished vasoreactivity leads to these problems, then let's do what can be done to increase vasoreactivity.
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cheerleader
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Re: Impaired Blood Flow in Diabetic Brain Tied to Cognitive

Post by cheerleader »

thanks for the paper, Cece--

The other MS, metabolic syndrome, has been linked to endothelial dysfunction for many years.
Metabolic syndrome is a term used to describe a cluster of problems in patients who are overweight, inactive, high glucose, diabetic, high blood pressure.
And endothelial dysfunction causes a disregulation in blood flow and diminished nitric oxide availability in people with metabolic syndrome.

Since the heart and brain are connected by blood vessels in and out, it makes sense that this would diminish cerebral blood flow and cause hypoperfusion.

Blood flow sure could be monitored in multiple sclerosis patients as it is in diabetics...but neuroimmunologists are still saying blood flow doesn't matter in this "MS".
we're in the midst of a paradigm change...
in the mean time, we can increase our own vasoreactivity,
http://www.ccsvi.org/index.php/helping- ... ial-health

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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