new research: MS is a vascular disease

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new research: MS is a vascular disease

Postby cheerleader » Thu Jul 16, 2015 2:07 pm

Newly published research from the ISNVD finds that pwMS do have endothelial microparticles in their blood, which are not found in normals. These microparticles are shed by dying and diseased endothelial cells, are a sign of endothelial dysfunction. They create inflammation, hypercoagulation and slow blood flow. These EMPs are related to lesions and brain atrophy in MS on MRI.

"Blood circulating microparticle species in relapsing–remitting and secondary progressive multiple sclerosis. A case–control, cross sectional study with conventional MRI and advanced iron content imaging outcomes" This paper is published in the Journal of Neurological Sciences.
http://www.jns-journal.com/article/S002 ... 3/abstract

Endothelial dysfunction is real, it changes serum and affect pwMS.
Here's a new blog post on the research:
http://ccsviinms.blogspot.com/2015/07/n ... se-of.html

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: new research: MS is a vascular disease

Postby frodo » Wed Jul 22, 2015 3:00 pm

cheerleader wrote:Newly published research from the ISNVD finds that pwMS do have endothelial microparticles in their blood, which are not found in normals. These microparticles are shed by dying and diseased endothelial cells, are a sign of endothelial dysfunction. They create inflammation, hypercoagulation and slow blood flow. These EMPs are related to lesions and brain atrophy in MS on MRI.

"Blood circulating microparticle species in relapsing–remitting and secondary progressive multiple sclerosis. A case–control, cross sectional study with conventional MRI and advanced iron content imaging outcomes" This paper is published in the Journal of Neurological Sciences.
http://www.jns-journal.com/article/S002 ... 3/abstract

Endothelial dysfunction is real, it changes serum and affect pwMS.
Here's a new blog post on the research:
http://ccsviinms.blogspot.com/2015/07/n ... se-of.html

cheer


They know that the endothelium is involved since long ago, for example http://www.ncbi.nlm.nih.gov/pubmed/11315981 , but this does not necessarly mean that it is primary vascular. It could be a secondary effect.

But it would be good to finally have a test for diagnosis. This current diagnosis based in clinical findings is close to prehistoric and delays research.
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Re: new research: MS is a vascular disease

Postby cheerleader » Thu Jul 23, 2015 11:00 pm

Yes, you're right, Frodo. Researchers have known about endothelial dysfunction in MS for over 15 years now. But it's now been shown that endothelial dysfunction is correlated to MS disease progression, lesions and brain atrophy. Relieving ED it could help improve symptoms and slow progression. Isn't that something worth investigating?

That's been my thought for 8 years now. Once Jeff was on the endothelial health program for 3 months, he never ever had these blood markers out of range again (high SED rate, high d-dimer, high ESR) and he has had no MS progression. Yes, he is anecdotal evidence, and he has benefitted from venoplasty for CCSVI as well....but we can do more than use these micro particle blood markers for diagnosis. We can diminish them (as cardiovascular researchers have done), get blood numbers in normal range, improve endothelial health, and help people with MS. That's all I'm sayin'....

here's the program. Anyone else want to try it?
http://www.ccsvi.org/index.php/helping- ... ial-health

cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Re: new research: MS is a vascular disease

Postby daniel » Tue Oct 27, 2015 3:56 pm

cheerleader wrote:That's been my thought for 8 years now. Once Jeff was on the endothelial health program for 3 months, he never ever had these blood markers out of range again (high SED rate, high d-dimer, high ESR) and he has had no MS progression. Yes, he is anecdotal evidence, and he has benefitted from venoplasty for CCSVI as well....but we can do more than use these micro particle blood markers for diagnosis. We can diminish them (as cardiovascular researchers have done), get blood numbers in normal range, improve endothelial health, and help people with MS. That's all I'm sayin'....

here's the program. Anyone else want to try it?
http://www.ccsvi.org/index.php/helping- ... ial-health

cheer


joan, where can we find more info re:which blood markers to ask our GPs to order tests for us?
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Re: new research: MS is a vascular disease

Postby frodo » Thu Oct 29, 2015 11:52 am

Another article that supports the previous one. OCT of the eye shows vascular problems.

http://europepmc.org/abstract/med/26485541

To evaluate the choroidal thickness in patients with multiple sclerosis (MS) using enhanced depth imaging optical coherence tomography (EDI-OCT).In this observational comparative study, 68 eyes of 34 MS patients and 60 eyes of 30 healthy subjects were evaluated. All participants underwent complete ophthalmologic examination and OCT scanning. Choroidal thickness measurements were performed at seven points.

The mean subfoveal choroidal thickness was reduced significantly in MS patients (310.71 ± 61.85 μm) versus healthy controls (364.85 ± 41.81 μm) (p < 0.001). The difference was also significant at all six measurement points (p < 0.001 for all). Choroidal thickness measurements revealed no significant difference between MS eyes with a prior optic neuritis (ON) history (MS ON) and those without ON history (MS non-ON). Subfoveal choroidal thickness did not correlate with retinal nerve fiber layer and Expanded Disability Status Scale score, but reduced choroidal thickness was associated with longer disease duration (r = -0.28, p = 0.019) in MS patients.In MS patients, choroidal structural changes occur both in MS ON and MS non-ON eyes.

The decreased choroidal thickness might provide evidence to support a potential role of vascular dysregulation in the pathophysiology of MS.
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