Dr. Alireza Minagar

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Dr. Alireza Minagar

Postby Cece » Wed Mar 08, 2017 12:36 pm

http://www.ctvnews.ca/health/study-find ... -1.3315927

Dr. Alireza Minagar, a U.S. neurologist who specializes in MS and teaches at Louisiana State University, says he has always been intrigued by the CCSVI theory and the idea that the venous system has been implicated as a possible cause. He thinks despite this study’s latest findings, the concept deserves further research.

“While still in its infancy, CCSVI poses an enormously complicated idea, which requires more fundamental studies to understand its role in pathophysiology of MS,” he said in an email to CTV News.

He says it isn’t clear if any of the opened veins in the UBC study closed up again after treatment, which is called restenosis, nor whether blood flow actually improved in the treated group.

He applauded the UBC group for tackling the study, but says the preliminary findings pose more questions that need to be studied.
“As a neurologist, I would suggest that the methods employed in this study be scrutinized more meticulously before ‘shelving’ this concept entirely, particularly when venous stenting approaches are increasingly being validated for other neurovascular complications.”

Dr. Alireza Minagar is an MS specialist at Louisiana State University who is saying similar things to what we are saying here regarding the UBC study design not looking at measurements of restenosis before drawing conclusions.

I wonder if Dr Minagar wants to get involved with ISNVD or participate with an IR in CCSVI research. We could use his way of thinking. He also mentions that venous stenting approaches are being validated for other neurovascular complications and I wonder what those are specifically. That seems like a good argument.

Edited: Ah, I see the connection! Dr. Minagar is at LSU and so is Dr. J. Steven Alexander. They co-edited a book together this year called, "Inflammatory Disorders of the Nervous System." Dr. J. Steven Alexander is a CCSVI researcher.
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Re: Dr. Alireza Minagar

Postby lyndacarol » Wed Mar 08, 2017 2:10 pm

In 2006:
general-discussion-f1/topic2411.html#p15048

Multiple sclerosis as a vascular disease.

Neurol Res. 2006 Apr;28(3):230-5.
Minagar A, Jy W, Jimenez JJ, Alexander JS.
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
https://www.ncbi.nlm.nih.gov/pubmed/166 ... t=Abstract

Multiple sclerosis (MS) has traditionally been viewed and researched as an immune-mediated disease with principal emphasis on the role of activated inflammatory cells, oligodendrocytes and astrocytes in its pathogenesis. Abnormalities of cerebral endothelial cells (CECs) is an under explored facet of MS pathogenesis and vascular abnormalities play a crucial role in formation of the MS lesions and disease progress, at least in the initial stages of disease.

This review will focus on MS as a central nervous system (CNS) disease with a strong vascular constituent and examines abnormalities within CECs in MS and their role in the loss of blood-brain barrier and transendothelial migration of activated leukocytes into the CNS. One goal of this paper is to persuade and promote research on the endothelial abnormalities in pathogenesis of MS and to exploit existing knowledge on endothelial injury.

A deeper understanding of endothelial pathophysiology in MS may help develop effective treatments through stabilization of endothelial function, translating into delay or arrest of MS disease onset and disability in MS patients.
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