Color vision in multiple sclerosis

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Color vision in multiple sclerosis

Postby frodo » Mon Feb 05, 2018 9:41 am

Do you remember the reports about improvement after PTA? Not sure about the relationship, but is worth to read about.

Impairment of acquired color vision in multiple sclerosis: an early diagnostic sign linked to the greatness of disease.

https://www.ncbi.nlm.nih.gov/pubmed/29392642

To assess the type and degree of both red-green and blue-yellow color vision deficiencies of Calabrian males affected by multiple sclerosis.

MATERIAL: Eighty Calabrian male patients were enrolled (age range 18-70 years; mean age 40.6 ± 12.4 years) showing a disease duration mean of 10.6 ± 8.2 years (range = 0.5-46 years) coming from the Institute of Neurology, Magna Graecia University, Catanzaro. Optic neuritis present in the medical histories of the 21 patients does not influence color vision. Excluding seven colorblind subjects and one affected by a bilateral maculopathy, the analyzed sample group was 72. Seventy controls were matched for age and sex.

METHOD: An ophthalmologist examined all patients and controls in order to rule out diabetic retinopathy, cataracts, senile maculopathy, or ocular fundus' anomalies. The Ishihara test identified the colorblind patients. The City University Test screened for people with abnormal color vision by grading the severity of color vision deficiency. The second part of the City University Test as well as the Farnsworth Test confirmed both the color vision deficiency type and degree.

RESULTS: Fifty-one percentage (37/72) of the patients showing a color vision deficiency were subdivided into two subgroups: subgroup one showed red-green deficiency (57%, 21/37); subgroup two showed a coupled red-green and blue-yellow deficiency (43%, 16/37). Furthermore, we found two distinct curves showing a groove within the first 10 years of the disease. Both monocular and binocular analyses allowed us to identify the patients showing the monocular color vision deficiency, but they were well compensated by binocular vision.

CONCLUSION: We think that the majority of the patients with the red-green deficiency will develop the coupled red-green and blue-yellow deficiency in the latter years of multiple sclerosis.
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Re: Color vision in multiple sclerosis

Postby jimmylegs » Mon Feb 05, 2018 1:55 pm

interesting. would be neat to see serum zinc levels in these groups.

personally, i used to see purplish items as grey before restoring nutrient status.

i read lots at the time about eye structures, rods and cones, etc. zinc was key. also implicated in night vision. and an essential cofactor for vit A utilization. vit A, which as we know is why the old wives say carrots are good for your eyes :)

related

Zinc and the eye.
https://www.ncbi.nlm.nih.gov/pubmed/11349933

Vitamin and mineral deficiencies in the developed world and their effect on the eye and vision
http://onlinelibrary.wiley.com/doi/10.1 ... 531.x/full
"...Ocular and visual effects of a [zinc] deficiency
... Rod-mediated functions are initially more severely affected than cone-mediated vision. ... Colour vision may also be affected"

Zinc therapy for night blindness in cystic fibrosis
http://www.cysticfibrosisjournal.com/ar ... 69-1993(07)00163-4/abstract
"This is the first report of a supplemented CF patient presenting with clinical vitamin A deficiency to be successfully treated with zinc therapy alone. Therefore in addition to retinol supplementation, normalizing serum zinc levels may be important in maintaining the vitamin A status of CF patients. The interactions and synergistic effects between the two micronutrients are discussed"
odd sx? no dx? check w/ dietitian
DRI=MINIMUM eg bit.ly/1vgQclQ
99% don't meet these. meds/lifestyle can affect levels
status can be low in ms & other cond'ns
'but my results are normal'. typical panels don't test all
deficits occur in 'normal' range
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