Just wondering what treatment Zamboni was discussing when you wrote the following.
Also Zamboni mentioned that treatment had no effect whatsoever on the vascular pproblem, you have the problem whether you are on treatment or not.
mrhodes40 wrote:An earlier Zamboni paper this one on 89 patients with matched controls.
http://www.ms-info.net/Intracranial_Ven ... erosis.pdf
This paper outlines how the backjets and anomalies related thereto are assoicated with MMP9 adhesion mlecules and other factors already known to be common in MS........answered my question above!Therefore, venous reflux overloads microcirculation (Bergan et
al., 2006) and increases trans-mural pressure (Zamboni et al.,
2007); in MS, changes of microcirculatory MRI perfusional parameters,
have been shown to precede plaque formation in a longitudinal
study (Wuerfel et al., 2004). Furthermore venous reflux,
with consequent microcirculatory overload and increased transmural
pressure, facilitates erytrocyte diapedesis (Zamboni, 2006;
Bergan et al., 2006; Zamboni et al., 2007) resulting in increased
perivenous iron deposits demonstrated histologically also in MS
lesions (Adams, 1989; Adams 1988) and confirmed by advanced
MRI techniques (Haacke et al., 2005; Tjoa et al., 2005; Brass et al.,
2006). Moreover, the excess of stored iron in the brain triggers a
series of deleterious events that lead to neurodegeneration, possibly
involving mechanisms of iron-driven free radicals generation and
oxidative stress (Ke et al., 2003,
Thanks for posting the earlier Zamboni study, Marie. I think Dignan had this one on our iron thread, but so much has been posted recently, I may be mistaken
Abstract: In multiple sclerosis (MS) plaques are known to be venocentric; in addition, MS lesions and peripheral venous disorders share
a number of key features. To date, however, despite the anatomical relationship between MS lesions and the venous system, no information
on the intracranial venous haemodynamics of MS is available. Eighty-nine consecutive MS patients (58 relapsing-remitting, 31 secondary
progressive) matched with 60 controls underwent transcranial color-coded duplex sonography (TCCS). We assessed, in supine as
well as in sitting positions, the direction of flow at the activation of the thoracic pump in the deep middle cerebral veins (dMCVs), and in
the transverse sinus (TS). In the dMCVs, we also measured peak systolic velocity (PSV), peak diastolic velocity (PDV), as well as the resistance
index (RI). Reflux/bidirectional flow rate was significantly higher in the MS population determining also significant differences
in PDV, characterized by negative values (16.2±1 cm/sec in controls vs. –1.3 ±2.6 cm/sec in MS, respectively, p<0.0001). Consequently,
RI was dramatically increased in the MS group, affecting impedance of cerebral venous drainage (0.48±0.04 in controls vs. 1.1 ±0.08 in
MS, respectively p<0.0001). Therefore, the detection of reflux directed toward the subcortical grey matter was significantly associated to
highest disability scores (p < 0.0001). Our study of MS patients demonstrated significant haemodynamic alterations detected in veins
anatomically related to plaque disposition. Our findings should contribute towards understanding the role of altered venous flow and tissue
drainage in the MS inflammatory chain, as well as in the neurodegenerative process.
Key Words: Multiple sclerosis, transcranial color-coded duplex sonography, cerebral veins, venous haemodynamics
...The authors have summarized the current knowledge of the Doppler haemodynamics of the cerebrovenous system and propose a list of reproducible clinical parameters for its sonographic evaluation. In future, the development of this diagnostic technique could be of singular interest in iron-related inflammatory and neurodegenerative disorders like
Could this possibly be an emot-icon on the way there?mrhodes40 wrote:I'm beyond beside myself..........
Any ideas on how it explains the Faroe Islands?mrhodes40 wrote:This model here in this thread seems right to me, it's novel, it is based on an indisputable fact that is ignored by regular medicine, and it accounts for a lot of what is going on in MS.
This is the one item that would be missing from both mrhodes and my pack for our ultrasounds.cheerleader wrote:Dr. Paolo Zamboni will be presenting his "Rationale and preliminary results of endovascular treatment for multiple sclerosis at Charing Cross (CX) vascular symposium in April of '09
Surgical treatment of vertebral artery insufficiency in patients with diagnosis of multiple sclerosis.
Nine patients with signs and symptoms of vertebral-basilar artery insufficiency and with the diagnosis of multiple sclerosis experienced partial restoration of lost neurologic function with the revascularization of ischemic tissue of the hindbrain by an operation to correct partial extraluminal obstruction of the proximal segment of the first part of the vertebral artery. The selection of patients is dependent on preoperative angiography of the aortic arch with visualization of the vessels of the neck, the vertebral and the carotid arteries. There was no mortality and no significant morbidity among these patients.
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