CCSVI RESEARCH here

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: CCSVI RESEARCH here

Postby MSUK » Mon Jul 15, 2013 12:53 am

Chronic cerebrospinal venous insufficiency: masked multimodal imaging assessment

Abstract

Background: Chronic cerebrospinal venous insufficiency (CCSVI) was implicated in the pathophysiology of multiple sclerosis (MS).

Objective: We evaluated neurosonography (NS), magnetic resonance venography (MRV), and transluminal venography (TLV) in subsets of MS patients drawn from a single-center, prospective, case-control study of 206 MS and 70 non-MS volunteers..... Read More - http://www.ms-uk.org/index.cfm/ccsviresearch
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Re: CCSVI RESEARCH here

Postby brocktoon » Tue Jul 16, 2013 9:36 pm

This is more of an anatomical paper rather than flow-related, but relevant to evaluating IJVs using two different MR sequences using a larger cohort of healthy controls than past papers.


M. Tamizur Rahman, Sean K. Sethi, David T. Utriainen, J. Joseph Hewett, E. Mark Haacke, A comparative study of magnetic resonance venography techniques for the evaluation of the internal jugular veins in multiple sclerosis patients, Magnetic Resonance Imaging, Available online 12 July 2013, ISSN 0730-725X, http://dx.doi.org/10.1016/j.mri.2013.05.012.

http://www.sciencedirect.com/science/ar ... 5X13002117
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Re: CCSVI RESEARCH here

Postby MSUK » Thu Jul 18, 2013 2:59 am

CCSVI is not associated with cognitive impairment in multiple sclerosis

Chronic cerebrospinal venous insufficiency (CCSVI) has been reported in multiple sclerosis (MS) yet its significance in relation to cognitive function is undetermined.This study measured the association between the presence and severity of CCSVI and cognitive impairment in patients with MS..... Read More - http://www.ms-uk.org/index.cfm/ccsviresearch
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Re: CCSVI RESEARCH here

Postby MSUK » Thu Aug 15, 2013 12:12 am

Reasearchers split on theory that MS is vascular disease

Hamilton researchers believe they have debunked a radical new theory that multiple sclerosis is a vascular disease which can be treated by opening up blocked veins.

But a British Columbia researcher says his work has opposite results to the study affiliated with McMaster University, St. Joseph's Healthcare and Hamilton Health Sciences published online Wednesday by the medical journal PLOS ONE......... Read More - http://www.ms-uk.org/index.cfm/ccsviresearch
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Re: CCSVI RESEARCH here

Postby DougL » Thu Aug 15, 2013 3:57 am

squiffy2 wrote:Reasearchers split on theory that MS is vascular disease

Hamilton researchers believe they have debunked a radical new theory that multiple sclerosis is a vascular disease which can be treated by opening up blocked veins.

But a British Columbia researcher says his work has opposite results to the study affiliated with McMaster University, St. Joseph's Healthcare and Hamilton Health Sciences published online Wednesday by the medical journal PLOS ONE......... Read More - http://www.ms-uk.org/index.cfm/ccsviresearch

"They did a great job just not good enough for me," said Traboulsee of the Hamilton study. "They've addressed it can't be determined with MRI and ultrasound but they haven't addressed if it exists because they didn't use the gold standard (test)."

same old story
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Re: CCSVI RESEARCH here

Postby erinc14 » Thu Aug 15, 2013 6:15 am

"same old story"

i'll say
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Re: CCSVI RESEARCH here

Postby Cece » Sat Aug 31, 2013 9:38 pm

http://link.springer.com/chapter/10.100 ... -7312-1_78

a 10 page publication on CCSVI by Dr. Siskin
alas I have no access to it!
Endovascular Interventions
2014, pp 979-991
Jugular Interventions for Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency
Jason P. Vachon MD, Gary P. Siskin MD

Who is Dr. Jason Vachon?
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Re: CCSVI RESEARCH here

Postby erinc14 » Sun Sep 01, 2013 6:46 am

Cece wrote:http://link.springer.com/chapter/10.1007/978-1-4614-7312-1_78

a 10 page publication on CCSVI by Dr. Siskin
alas I have no access to it!
Endovascular Interventions
2014, pp 979-991
Jugular Interventions for Multiple Sclerosis and Chronic Cerebrospinal Venous Insufficiency
Jason P. Vachon MD, Gary P. Siskin MD

Who is Dr. Jason Vachon?

what does it say ?
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Re: CCSVI RESEARCH here

Postby Cece » Sun Sep 01, 2013 4:05 pm

I don't know, it's behind a paywall.
I think it's a review with images of procedures that they've done.
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Re: CCSVI RESEARCH here

Postby MSUK » Tue Sep 10, 2013 12:32 am

Clinical trial into MS 'liberation treatment' cancelled due to lack of participants

Canadians who were among multiple sclerosis patients waiting to take part in a clinical trial into the so-called liberation treatment were disappointed on Monday by news that the trial was cancelled.

The Saskatchewan government was told that the Albany Medical Centre in New York has stopped its trial into the effectiveness of angioplasty in treating CCSVI (chronic cerebro-spinal venous insufficiency) and relieving symptoms of multiple sclerosis. The treatment involves opening blocked neck veins..... Read More - http://www.ms-uk.org/index.cfm/ccsviresearch
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Re: CCSVI RESEARCH here

Postby MSUK » Mon Sep 23, 2013 11:30 pm

CCSVI: early self-reported benefits are not sustained at follow-up interview

Abstract

Background: Venoplasty with or without intravascular stents (the “liberation” treatment) has been proposed as a treatment for multiple sclerosis (MS) patients with radiologic findings suggestive of Chronic Cerebrospinal Venous Insufficiency (CCSVI). The purpose of the British Columbia (BC) CCSVI Registry is to gather information on safety and efficacy from MS patients in BC, Canada who have received the “liberation” treatment abroad......Read More - http://www.ms-uk.org/ccsviresearch
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Re: CCSVI RESEARCH here

Postby MSUK » Mon Sep 30, 2013 1:57 am

CCSVI not a causative factor in pathogenesis of MS - study

Abstract

Objectives & Methods: We evaluated internal jugular vein and vertebral vein volume flow using ultrasound, in patients with clinically isolated syndrome or mild multiple sclerosis and controls, to determine whether volume flow was different between the two groups..... Read More - http://www.ms-uk.org/ccsviresearch
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Re: CCSVI RESEARCH here

Postby MSUK » Wed Oct 09, 2013 12:50 am

No link between narrowed veins and MS: Canadian-led study

A study published in the British medical journal The Lancet finds that narrowing of the veins leading from the brain -- a condition called CCSVI -- is just as prevalent in patients with Multiple Sclerosis as in people without the disease.

The study, funded by the MS Society of Canada and led by Dr. Anthony Traboulsee of the University of British Columbia, calls into question the controversial theory that MS is caused by or associated with CCSVI, or chronic cerebrospinal venous insufficiency...... Read More - http://www.ms-uk.org/ccsviresearch
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Re: CCSVI RESEARCH here

Postby frodo » Mon Oct 28, 2013 6:59 am

Article from Hans Lassmann, one of the current main researchers. He has performed an "atlas" of the venous system and concludes:

The vein-atlas illustrates the average venous network of the control group. The venous volume portion in MS lesions was significantly higher (P < 0.05) compared with the corresponding regions in the vein-atlas. NAWM regions did not differ significantly (P > 0.05) from corresponding atlas regions.

Source: http://www.ncbi.nlm.nih.gov/pubmed/24151233
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Re: CCSVI RESEARCH here

Postby vesta » Sun Nov 03, 2013 12:43 pm

We can now see that symptoms of paralysis require a thorough examination of the structure surrounding the central nervous system – veins, arteries, cerebrospinal fluid, bones, muscles ligaments. Only then can a diagnosis and appropriate treatment be proposed. For some reason Neurologists seem unwilling to do this. And the Big Pharma/Neurology lobby with the assistance of the FDA and national MS Societies (MS-UK for instance) are doing all in their power to impede development of CCSVI diagnosis and treatment for MS.
Unfortunately, MS CCSVI is too easily discredited by the insistence of Angiologues to monopolize CCSVI treatment through Angioplasty. A “Skeletal” MS implies that pressure or restriction ON the vein rather than stenosis IN the vein is the problem and for this Angioplasty will prove fruitless, if not deleterious. It is touching of MS-UK to report multiple “scientific” studies discounting CCSVI MS on the Thisisms.com website. “Touching” but unhelpful. What would be really helpful is a thorough survey of the approximately 30,000 Angioplasties performed thus far for MS. But of course this will never happen because CCSVI treatment for MS has been driven underground, the techniques and competences are varied and follow-up care sketchy (thanks to interest groups like MS-UK).
Word is getting out.
Note the following post by Wendy Hess on CCSVI Locator October 25, 2013

""All heavy metals can cause lesions on an MRI if they accumulate in a sensitive area as is the nervous system ( and lesions lead to an MS diagnosis). Heavy metals can come from toxic exposure OR from improperly digested nutrients, like Iron, that don't exit the body in normal excretion process. The reason they get to be a problem in the brain/spinal column is if the CSF (Cerbral Spinal Fluid) flow is disturbed , impaired, or in back flow where the body cannot flush them out normally ; they accumulate and block the -nutrients in/ waste products out -cycles . This is explains why spinal taps can confirm diagnosis- high T cell counts go to the aid of the nervous system, but cannot really help there because it is a physical problem that needs addressing!
How does this happen? Many skeletal disruptions from whiplash, accidents, the birth process, or skeletal genetics can impede CSF flow. Resulting lesions can sometimes, but not always, take years to do damage and be realized in MS type symptoms. Heavy metals can accumulate and become deposited to block blood flow. One day, the answer to the MS riddle will be uniformly recognized as the result of obstruction from a COMBINATION of CSF and Vascular flow. That's the piece of the puzzle Zamboni needs to recognize,too. If heavy metals (Iron included) cannot leave the central nervous system as the body has intended, and they accumulate to block nerve transmission, eventually lesions and subsequent possible disability are expressed. It begins in obstruction of the CSF flow. xxx""

Recently on Thisisms.com a Mother of a 10 year old boy who developed “MS” symptoms after an accident reported that Ayurvedic treatment helped him. (She refused MS drug treatment for him.) The following was my response.
““About 15 years ago a badly handicapped French woman told me that while in India she had enjoyed an Ayurvedic massage in which several women worked on her and afterwards she could walk normally again. This made no sense to me at the time, but now I realize she must have CCSVI venous stenosis. Her testimony resembles that of successful balloon angioplasty which opens the venous blood flow in MS patients implying that the massage opened up blood flow to the Central Nervous System. Upon returning to France she lost the benefits of the treatment. Acupuncture helped her, probably by enhancing blood circulation, but nothing like the dramatic improvement in India. She probably has a serious vein stenosis and is in need of angioplasty (or needs daily massages- an unlikely possibility) OR needs treatment for some kind of skeletal obstruction of CNS blood/cerebrospinal fluid flow.””
Now tell me, MS-UK, if a 10 year old (or 7 year old) child who has suffered a head/neck/spine injury comes in with “MS” like symptoms, are you really going to put him on DMDs? Wouldn’t it be better to see how the body structure impacts CNS fluid dynamics, (Blood/CSF flow) and correct the physical injury?
I wish the Big Pharma/Neurology lobby, their MS Societies, and the FDA would butt out of my business.
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