CCSVI RESEARCH here

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: CCSVI RESEARCH here

Postby CureOrBust » Sat Nov 09, 2013 9:33 pm

This paper is a little old now, and is only a review of other studies. However, it does provide at least two interesting items. The first being that it lists a few ongoing trials which met their criteria for being a valid trial, and the second interesting thing when I was reading it was, in the "Declarations of interest" (ie Conflict of interest) section, one of the authors had undergone the procedure. 8O

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD009903.pub2/full
The basic results are summarised by their statement:
There is currently no high level evidence to support or refute the efficacy and safety of PTA for the treatment of CCSVI in participants with multiple sclerosis.


For example I searched one of the incomplete studies and it gave me https://www.anzctr.org.au/Trial/Registr ... 2000302853 which apears to be a trial by the hospital that actually performed my second procedure. The Dr spoke about this trial he was trying to get started. Obviously he had to get it done OS in New Zealand.
References to ongoing studies
ACTRN12612000302853 {published and unpublished data} ACTRN12612000302853. A randomised, blinded, controlled study of percutaneous transluminal angioplasty (PTA) for extracranial vein stenoses in patients with multiple sclerosis (MS). http://www.anzctr.org.au.
NCT01089686 {unpublished data only} NCT01089686. Study to evaluate treating chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis patients. http://www.clinicaltrials.gov.
NCT01201707 {unpublished data only} NCT01201707. Evaluation of angioplasty in the treatment of chronic cerebrospinal venous insufficiency (CCSVI) in multiple sclerosis. http://www.clinicaltrials.gov.
NCT01371760 {unpublished data only} NCT01371760. BRAVE-DREAMS (BRAin VEnous DRainage Exploited Against Multiple Sclerosis). http://www.clinicaltrials.gov.
NCT01450072 {unpublished data only} NCT01450072. Prospective randomized endovascular therapy in multiple sclerosis - PREMiSE. http://www.clinicaltrials.gov.
NCT01555684 {unpublished data only}
Maybe one of these has completed.
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Re: CCSVI RESEARCH here

Postby CaveMan » Mon Nov 11, 2013 10:15 pm

This has already been covered up a bit already,
Just thought I'd post up anyway, I was looking into the whole CCSVI thing to see how it related to my ideas and what basis there was, I never paid much due to it as a causal factor, it did not really seem to fit with what I knew of MS.
The folowing studies seem to confirm my thoughts, that there isn't much evidence as a causal factor, but more so that CCSVI like symptoms may be evident in some individuals and the procedure may help relieve these a bit, but is not a cure.
http://www.ncbi.nlm.nih.gov/pubmed/21280079
http://www.ncbi.nlm.nih.gov/pubmed/23778162
http://www.ncbi.nlm.nih.gov/pubmed/23250108
http://www.ncbi.nlm.nih.gov/pubmed/20127806
I am just an interested individual trying to crack the autoimmune nut.
Partner has Graves Disease, 5 years, showing good test results, looking forward to potential remission in the near future.
3 friends have MS, 1 just recently diagnosed, severity 7/10.
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Re: CCSVI RESEARCH here

Postby MSUK » Fri Nov 22, 2013 4:26 am

MS patients did not benefit from CCSVI intervention - PREMiSe study

Multiple sclerosis (MS) is a disease of uncertain etiology characterized by demyelinating lesions affecting the central nervous system. In 2009, Dr. Paolo Zamboni et al described an association between MS and extra cranial venous outflow restrictive lesions detected by extra cranial and intracranial venous duplex studies........ Read More - http://www.ms-uk.org/ccsviresearch
MS-UK - http://www.ms-uk.org/
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Re: CCSVI RESEARCH here

Postby zjac020 » Fri Jan 03, 2014 2:12 pm

Just came across this basic study. Very interesting although for obvious reasons they avoid making any reference to CCSVI, wonder why...

http://www.nature.com/jcbfm/journal/v34 ... 3161a.html
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Re: CCSVI RESEARCH here

Postby CureOrBust » Fri Jan 03, 2014 7:01 pm

zjac020 wrote:Just came across this basic study. Very interesting although for obvious reasons they avoid making any reference to CCSVI, wonder why...

http://www.nature.com/jcbfm/journal/v34 ... 3161a.html

They probably made no explicit reference to CCSVI as they were specifically looking at Arterial, not venous flows.
Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing–remitting MS.
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