Diminished Visibility of cerebral venous vasculature in MS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Diminished Visibility of cerebral venous vasculature in MS

Postby cheerleader » Fri May 01, 2009 12:42 pm

ABSTRACT
Multiple sclerosis (MS) is a disease of the central nervous system characterized by widespread demyelination, axonal loss and gliosis, and neurodegeneration; susceptibility-weighted imaging (SWI), through the use of phase information to enhance local susceptibility or T2* contrast, is a relatively new and simple MRI application that can directly image cerebral veins by exploiting venous blood oxygenation. Here, we use high-field SWI at 3.0 Tesla to image 15 patients with clinically definite relapsing-remitting MS and to assess cerebral venous oxygen level changes. We demonstrate significantly reduced visibility of periventricular white matter venous vasculature in patients as compared to control subjects, supporting the concept of a widespread hypometabolic MS disease process. SWI may afford a noninvasive and relatively simple method to assess venous oxygen saturation so as to closely monitor disease severity, progression, and response to therapy.

link

This new research (april '09) shows less visibility of veins in MS brains due to a hypometabolic state (slowed down metabolism due to less oxygenation)
Less oxygen and slowed down metabolic activity could be certainly be caused by chronic cerebrospinal venous insufficiency.

NOTE: Study done at NYU School of Medicine...they have lots of studies on venous/MS connections. And they have MRV technology. Can someone contact them re: CCSVI?
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby mrhodes40 » Fri May 01, 2009 1:32 pm

We talked about that one on page 42 too-- deoxyhemoglobin comments
This is a huge mungous thread :lol:
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Postby cheerleader » Sat Jan 09, 2010 11:35 am

I am bumping this thread, because the Ge et al research on diminished visibility of venous vasculature in MS is an issue that Dr. Mark Haacke is currently picking up in his new research, looking at oxygenation usage in MS brains.
Recommended reading for all new to CCSVI-
cheer

RESEARCH is the key
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby thisisalex » Sat Jan 09, 2010 1:40 pm

cheerleader wrote:I am bumping this thread, because the Ge et al research on diminished visibility of venous vasculature in MS is an issue that Dr. Mark Haacke is currently picking up in his new research, looking at oxygenation usage in MS brains.


Cheer,

you're right, i have just read about it in Haacke's new presentation from yesterday

http://www.ms-mri.com/presentations/Imaging%20Iron%20in%20MS%20using%20Susceptibility%20Weighted%20Imaging%20(SWI).pdf

page Nr 29 is about this issue, with illustrations. amazing.

alex
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