I don't know exactly what one is, however, maybe Dr Dake should speak with a Phlebologist? The next presentation involving this theory is at a Phlebologist conference. Dr Simka appears to be heavily involved with this research, and is also part of that next presentation.cheerleader wrote:It seems that our first four Stanford patients need more coumadin than the "average" patient, who only needs 5mg. to get the blood thin enough for stent patency.
We need to get hematologists involved in this research. I'll talk to Dr. Dake about it when we go back in July.
Blood-Clotting Protein Linked to Rheumatoid Arthritis
Research shows that fibrin, a protein normally involved in blood clotting, also plays an important role in the inflammatory response and development of rheumatoid arthritis
Fibrin deposits are a prominent feature of arthritic joints, and the protein appears to be a link between systems that control inflammation and bleeding within joints, according to a study funded by the Arthritis Foundation and published in the Journal of Clinical Investigation. Lead author Jay Degen, PhD, and his colleagues explain that in arthritic joints, the meshlike matrices formed by fibrin to create blood clots may control local activity of inflammatory cells as well as support inappropriate tissue reorganization.
The study suggests that inflammatory disease is driven by the inflammatory cells within fibrin matrices through a specific protein in the plasma membrane called aMB2. If that is so, developing medications that can stop the interaction between fibrin and aMB2 might help treat RA as well as many other inflammatory diseases, such as multiple sclerosis, says Degen, a researcher in developmental biology at Cincinnati Children’s Hospital.
cheerleader wrote:Holly, you should be proud of yourself for being so brave, undergoing an experimental treatment, and paving the way for others with PPMS. We all owe you a huge debt of gratitude- a day at a time,cheer
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