Lord I cen't believe I am burying my own post but this one is super -duper great
The ultrastructural changes of cutaneous and subcutaneous capillaries and venules in 6 cases of severe, chronic venous insufficiency were examined. The findings in all cases consisted of numerous and characteristic alterations of the vessel wall structure and of the pericapillary space which are supposed to be due to the increased intravenous pressure.
Did I mention my pressure on the brain side of the stenosis dropped after the stent was placed?
The intercellular spaces are enlarged to wide channels through which erythrocytes pass into the perivascular spaces. Microvesicles occur in great numbers, they are arranged in chain-like formations and seem to come together to form transendothelial channels. Around the capillaries, edematous fluid with proteins and erythrocytes accumulates. Phagocytosis of erythrocytes, siderosomes and collagen fibrils by macrophages is observed. Within the endothelial cells there is an abundance of Weibel-Palade bodies and of multivesicular bodies. The former are frequently seen in contact with the luminal cell membrane. Weibel-Palade bodies are believed to be involved in the clotting mechanism.
This one is so full of stuff I will have to break it down a little
The intercellular spaces are enlarged to wide channels through which erythrocytes pass into the perivascular spaces.
means that the red blood cells can pass through into the tissue because of the venous backup.....
Microvesicles occur in great numbers, they are arranged in chain-like formations and seem to come together to form transendothelial channels
means tiny blood vessel like structures are created that make channels through the endothelium making it leaky...so it's like your pipe is now like a soaker hose instead of a tight line.
Around the capillaries, edematous fluid with proteins and erythrocytes accumulates
this means fluid goes into the tissue (brain in CCSVI)............. can anyone say "enhancing lesion??" because Gd will go right through there in that site.
Phagocytosis of erythrocytes, siderosomes and collagen fibrils by macrophages is observed
this means the immune system comes in to clean up.
Ok then add that to this comment from the paper "MS is a neurodegenerative disease a thought exeriment" by Timothey Vartanian MD (my personal collection) from a table showing a pattern of demyelination
degeneration of distal oligodendrocyte processes followed by oligodendrocyte apoptosis and demyelination
that means the arms of the oligodendrocyte that are farther way are damaged and it causes the whole oligo to die as a result...it can't survive an arm being cut off
and NOW add to that the idea I mentioned before based on Schellings paper page 30 where he mentions and references that different authors have put forth the idea that only if there is inflammation first can there be demyelination and you can see how the fluid leaking out through those microvascular would push the oligodendrocytes away frone the axons and break the "distal processes" (the arms that are farther away) which are warpped around the axons. Suddenly the whole oligodendrocyte would be gone and so is the myelin.
I feel like a quick draw old west sharp shooter zinging stuff at the autoimmune theory---Feeeeew...feww..fewww...fewww blow the smoke off my guns and spin em back to my holster.....
this is speculative of course..........
I'm not offering medical advice, I am just a patient too! Talk to your doctor about what is best for you...
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