Vascular malformations are from embryological defective vessels involved in the later stages of embriogenesis. CVM can develop anywhere in the vascular system as a birth defect. The vascular malformation is one of the CVMS which affects mainly the venous system. There is much we do not know, and we do not know how much we do not know.
Two classifications of venous malformations:
Extratruncular- this is formed by embryonic tissue remnant which carries a risk of growth, because it is mesynchymal. When stimulated by hormones, pregnancy, etc, it can reactivate and grow.
Truncular VM- this is formed as part of the later stage of embryonic development. This form does not have mesencymal cell characteristics. Truncular lesions present as a fetal remnant- such as sciatic veins or superior vena cava malformations
From the finalized notes, Dr Lee's comments.
He is looking at it as a congenital issue it seems to me. There was also the person presenting the genetics.
However I have said before that to me it seems that a person could have ANYTHING be at cause, if you were in a car accident at 16 and your neck got crushed and they repaired it but you had one jug severely pinched/ scarred, might that person get MS at 50? Seems to me that this pathology/model would say that they would.