However, my larger question remains: if an auto-antibody could be identified for MS, and the cure would be simply to block this antibody, why isn't this done with proven auto-immune diseases.
Because you are thinking tha tother diseases are proven autoimmune ones and most are not. Most are like MS and they do not have a proven antigenic target.
But a true autoimmune disease is when the body mistakenly makes an antibody to a antigen on itself. A good example is ADEM.
In ADEM you get a shot for rabies and it causes a cross reaction with your brain antigens in some people and the myelin is attacked. So the brain tissue LOOKS LIKE the rabies peptide sequence and that is how the mistake happens.
Once the mistake happens it is this antibody going into the brain and causing damage to otherwise perfectly healthy tissue--
Obviously if you block that antibody the damage does not happen. End of disease.
The problem is most of our "autoimmune diseases" don't have an antigenic target if they did they could fix them this way. That was how tovaxin was supposed to work.
here's the dirty little secret: the proven autoimmune diseases like ADEM are self limiting. They end in just a little while because your body knows better than to keep whacking itself that way....
Just like EAE is self limiting and it ends.
And rheumatic fever
nobody makes an antibody for these to block them because they are self limiting. It would not make money for the company to do so.
But in theory if we can find the antigenic target and the errant antibody and we can block it in any auto immune disease the disease would stop because the disease IS nothing more than that bad antibody attacking.
I'm not offering medical advice, I am just a patient too! Talk to your doctor about what is best for you...
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