jimmylegs wrote:whoops well that didn't work - i'll try to fix the map later :S
lyndacarol wrote:turtle_fi-- I have some general questions about the area in western Finland that you mentioned as having many cases of MS.
Has it been established that these cases of MS are in people who are related? If people in your country do not move away from family often, over time people in a given area may have common ancestors.
I believe that excess insulin secretion from the pancreas is fundamental to MS. Under this belief, it seems to me that a type of pancreatic function (or dysfunction) could be found among members sharing an ancestor. Or maybe food habits or diet could be similar in such a group?
Unlike PROG, VDH protects against the toxic effects of heme breakdown products.
It efficiently maintains intracellular calcium (38,39) and has been reported to protect cells from free heme-induced oxidative injury by upregulating glial heme oxygenase-1 immunoreactivity associated with the reduction in GFAP (glial fibrillary acidic protein) immunoreactivity in cortical regions affected by focal cortical ischemia (40).
Furthermore, VDH is also known to exert a regulatory effect on the renin-angiotensin system by suppressing renin biosynthesis and regulating blood pressure homeostasis (41–43).
Another important feature of VDH is its role in growth and regeneration mediated by nerve growth factor and glial-derived neurotrophic factor (44,45).
Our finding that VDH significantly enhances the neuroprotective efficacy of PROG in combination also suggests that PROG could be given to prevent the initial inflammatory cascade and edema, and then be coupled with VDH to stimulate the neurotrophic and regenerative events that take place later in the reparative process.
...but wow what a great paper I am so glad you picked up on it Sharon!heme is not my bag
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