"This patient proved to be unique in the history of multiple sclerosis in that there was lesion available for study that was less than a day old," said Prineas.
According to the dominant theory of MS, when the researchers examined the hours-old lesion, they should have found the beginnings of an immune system attack.
But Prineas and Barnett noticed that the myelin in the lesion was still intact, and there was no evidence that the typical armada of immune system cells and molecules had moved into the area yet. Instead, oligodendrocytes cells, which produce the myelin, were dying. Myelin is, in fact, an extension of oligodendrocytes that wraps itself around nearby nerve fibers.
Article Link: New Data Challenge Theories Of Multiple Sclerosis (ScienceDaily Feb. 23, 2004)
Could it be that the reflux of blood from blocked veins is what causes the death of oligodendrocytes? If this was found out 5 years ago... why is it taking so long for people to let go of the autoimmune theory? I guess funding controls a lot of how research proceeds unfortunately