Increasingly, elaboration of inflammatory cytokines appears key to the brain-based response to hypoxia, as evidenced by the biobehaviors of malaise, fatigue, lethargy, and loss of interest in the physical and social environment. These sickness symptoms implicate hypoxia-dependent activation of the neuroimmune system as a key component of acute hypoxia.
I've mentioned before that Jeff's first signs of his MS progression- which began 15 years ago, although he was only diagnosed 2 years ago- were depression, a lack of interest in socializing, bad sleep patterns and fatigue. Since his stenting procedure he is more social, more energetic, happier, sleeping better (no more SNORING, he is now a quiet sleeper.) He feels reborn.
It breaks my heart to read the general thread stories of depression, sleep disturbance, fatigue...afflictions that are not as apparent as a loss of motor function, but are no less crippling for a human being. Jeff was a 1.5 EDSS before his procedure, but there was no way to measure how MS/CCSVI had changed him. In retrospect, we can see what he had lost, and now what he has gained.