Personally I think it's best that people pm you with links to offensive remarks. There's no shortage IMO.
Now, back to the thread discussion. I remain interested in research and thought this abstract probably belonged here as well.
Immunological consequences of ischemic stroke: Immunosuppression and autoimmunity
Here we summarize current knowledge on the immunological consequences of ischemic stroke and will discuss implications of these findings for our understanding of the immunopathogenesis of Multiple Sclerosis.
I've never been into the immune gig with MS but one basic understanding of the article I have is that the authors are posing the question: Why does the autoimmune response stop in stroke and persist in MS?
The mechanisms which perpetuate this autoimmune process to result in chronic autoimmunity (MS) or curtail the local autoimmune response (stroke) are not completely understood.
At any rate, it seems like they do identify similarities in the immune response in stroke with that in MS.
An open access article by some of the same authors Functional status of peripheral blood T-cells in ischemic stroke patients
And, another abstract, while it's on stroke, these authors also do MS research. CD4(+)FoxP3(+) regulatory T-cells in cerebral ischemic stroke
Experimental cerebral ischemic stroke is exacerbated by inflammatory T-cells and is accompanied by systemic increases in CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Treg). To determine their effect on ischemic brain injury, Treg were depleted in Foxp3(DTR) mice prior to stroke induction. In contrast to a recent Nature Medicine report, our results demonstrate unequivocally that Treg depletion did not affect stroke infarct volume, thus failing to implicate this regulatory pathway in limiting stroke damage
Looks like the immune response in stroke is starting to be a "hot topic".
Joan--thanks for all your research and hard work. Please do keep posting here. There's a few of us still interested in research.
Oops, I nearly forgot this, the most recent FDA approved drug for MS also shows some promise in stroke. Fingolimod provides long-term protection in rodent models of cerebral ischemia
Take care all