Rokkit, thinking about this again, I guess we don't yet have a conclusive argument against my theory, that one edema in the brain can cause excessive myelin&venous tissue directed immune response, which could trigger a small lesion somewhere else.
I want to talk about my own history here as it's the one I know best. I'd intuitively say that the immune response to a pre-existing lesion must have played a major role there. I had no neurological and health issues prior to Dec 08, but had multiple symptoms in the first few weeks of Jan. One thing that can act as fast and as globally throughout the body and reach different areas of the CNS is the immune system. If I had to bet for one theory of what happened to me based on what I know now, I'd say that a sudden increase (of unknown origin) in stenosis&iron deposition in my brain lead to microbleeds and exposed nervous tissue, which lead to a strong immune response, which attacked other CNS areas, including along my spine. Interestingly mild numbness in the ball of my left foot, which could point to spinal involvement, started after a 3 week delay compared to the first (cerebral) symptoms. Now Marie provided an argument against that, saying that 99% of lesions in MS are typically found in venous outlets, whereas one would expect the lesions in my spine to be diffusely dispersed because they're caused by T cells, but by CCSVI in that area.
I think this question, how people with e.g. jugular vein problems only perfect azygos veins can have sacral spine symptoms that subside with jugular ballooning/stenting, is crucial to the CCSVI paradigm. I think we'll only be able to answer it if we resolve 1) which symptoms come from the spine and can NOT be attributed to the brain, 2) how far can venous issues (reflux, pressure, etc) due to jugular stenosis travel down the spine to cause these symptoms, and 3) are 99% of lesions in MS spines close to venous outlets.
Last edited by radeck
on Sun Jan 24, 2010 3:51 pm, edited 1 time in total.