Once the blood brain barrier has been perforated (via reflux, edema, leakage caused by a stenosis) and there's an immune system response against the exposed CNS-matter, this might also affect other areas, and cause new lesions by itself
However, T2-weighted images show ADEM lesions
that are more pronounced with poorly defined margins
in deep white matter and periventricular sparing.
If the spinal cord is involved it will show large,
swollen lesions that may extend into the thoracic
region from the cervical region (Dale & Branson,
2005). As a general rule, ADEM lesions in the spinal
cord are continuous lesions affecting multiple levels,
whereas a typical MS lesion is confined to one spinal
cord level. Any single lesion affecting more than one
spinal level should raise suspicion for ADEM in the
appropriate clinical picture. The typical MS lesions
are also posterior in location on axial, cross-sectional
views of the spinal cord, whereas the ADEM lesions
tend to be more diffusely present throughout the
(e.g. mild optic neuritis) and two weeks later a spinal-cord-based (numbness in left foot) symptoms, to mention just a few
This whole idea also would explain, at least in part, why the patients of the liberation procedure didn't experience complete stopping of their MS activity, but that the percentage of them that had new lesions went "only" from 50% to 12%, and relapse rate from 50% to 23% over two years respectively: there are still plenty of circulating myelin-reactive immune cells and antibodies that can cause further damage.
However once the root cause of the problem (the stenosis) has been fixed, one may hope that eventually those T-cells die off (if you have been immunized to a certain pathogen you need re-immunization a few years later as well
I thought that the only people that had relapses after surgery were the ones that had restenosis. I doubt that the adaptive immune system is the root of all evil. Besides, a stenosis of the jugulars could very well alter haemodynamics across the whole nervous system.
Just my thoughts.
radeck wrote:Also, one person visiting these threads told me he/she had jugular veins treated and subsequently experienced remission of bladder control problems, which is commonly attributed to a spinal lesion.
The preliminary results state this, so one can be as sure as much as one trusts that document.radeck wrote:I didn't know that the only ones who had relapses were the ones with re-stenosis. Do you know for sure? I guess we'll have to wait for the details of the paper.
Rokkit wrote:radeck wrote:Also, one person visiting these threads told me he/she had jugular veins treated and subsequently experienced remission of bladder control problems, which is commonly attributed to a spinal lesion.
The most common bladder problem is spastic bladder: you have to go all the time, and it is typically caused by a lesion in the brain. Less common is flaccid bladder: you can't tell you need to go so you retain urine and your bladder grows bigger and bigger. Flaccid bladder is typically caused by a spinal lesion.
I have never had any spinal lesions and I definitely have loss of function in my legs and feet including sensory losses. You can have only brain lesions and only jugular issues (as I do) and still have foot numbness and leg dysfunction.
catfreak wrote:marie wrote:I have never had any spinal lesions and I definitely have loss of function in my legs and feet including sensory losses. You can have only brain lesions and only jugular issues (as I do) and still have foot numbness and leg dysfunction.
I have never had any spinal lesions either (2 MRI's of the spine) and I have lots of numbness and spasms in my feet and legs. I also had a urinary tract infection and felt no pressure or pain also bowel problems.
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