marcstck wrote:Also, nerve cells release iron when they are damaged or die, so iron deposition in MS may be an effect, rather than a cause...
paulmur wrote:marc, what I know is that my iron went haywire due to a genetic propensity for it to happen.I don't believe that aspect of my health was related to ccsvi or ms. But perhaps the HH appearing with the ccsvi condition may have caused the lesions I have.
I think the fact that iron deposits appear with other diseases may just mean there are other sets of factors that could add up to the same result.
I haven't had any ccsvi imaging. For all I know, my lesions were caused by my HH alone.
This review focuses iron overload and oxidative stress as surrounding cause that leads to immunomodulation in chronic MS. Iron overload has been demonstrated in MS lesions, as a feature common with other neurodegenerative disorders. However, the recent description of chronic cerebrospinal venous insufficiency (CCSVI) associated to MS, with significant anomalies in cerebral venous outflow hemodynamics, permit to propose a parallel with chronic venous disorders (CVDs) in the mechanism of iron deposition. Abnormal cerebral venous reflux is peculiar to MS, and was not found in a miscellaneous of patients affected by other neurodegenerative disorders characterized by iron stores, such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis. Several recently published studies support the hypothesis that MS progresses along the venous vasculature. The peculiarity of CCSVI-related cerebral venous blood flow disturbances, together with the histology of the perivenous spaces and recent findings from advanced magnetic resonance imaging techniques, support the hypothesis that iron deposits in MS are a consequence of altered cerebral venous return and chronic insufficient venous drainage.
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