CCSVI might lead to MS (i.e. auto-immune issues). However this would lead to the question: where does CCSVI come from? There seems to be some evidence that it's congenital, but infections seem to also play a role. Dr. Dake says he can imagine that lymph inflammations in the neck (I suppose tonsils) can affect surrounding tissue as far as the jugular veins and make the stenosis worse. How much congenital versus infection matters is not clear at least to me, and what other factors might matter. There don't seem to be signs of auto-immune attacks against the vein walls though. It also isn't known yet as far as I know why veins of patients re-collapse and what can be done to prevent it (even stents don't seems to be a guarantee). Cheers thread about Frohman's work tries to tackle that question. We also don't know why veins throughout MS patients brains are missing by 40%, though I believe there's some evidence that this degeneration is caused by hypoxia (lack of oxygen). It would be good to hear from Zamboni&Salvi whether there is some re-building of cerebral venous structure in those patients that received the liberation procedure. cheer, do you have information on this? It would also be good to see the actual fraction of patients that had re-collapsed veins (not just the fraction of those that had relapses, and were then found to have re-stenosis).
Long answer, with lots of new questions...sorry...
Last edited by radeck
on Tue Jun 07, 2011 4:02 pm, edited 1 time in total.