radeck wrote:Dear L,
I can only give a hand-wavy answer to this. It seems to me that there are very roughly two modes of destruction of brain matter in MS: a) the-lack-of-oxygen-and-iron deposition mode, and b) the immune-system-doing-more-damage-while-it's-just-trying-to-clean-up-a-little-mess mode. Some people are more a) and others are more b). Why, I don't know. Maybe some people have more aggressive immune systems than others. In any event, within CCSVI theory the root of the problem is always lack of venous outflow and overall "ventilation" of the brain with oxygenated blood. This leads to attacks on the endothelium (lining of blood vessels), there is micro-bleeding, i.e. blood comes in contact with brain tissue, then the immune-system cleans up and in some patients (those with RRMS) freaks out a lot and causes much more damage than just the lack of "ventilation", then it calms down again starting a remitting phase.
LR1234 wrote:Thanks Rad
So, couldn't it be that the reflux blood agitates the brain tissue (and causes immune system response)...it becomes inflamed and when the inflammation subsides, you are left with the scar (lesion).
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