Well IVIG does not stop MS altogether. It does seem to help some people, but it is not a approved therapy as you mention.
If you go with the idea that CCSVI causes MS theoretically, ANYTHING that prevents inflammation is going to make MS seem better even if it is caused by CCSVI.
The reason is that as the leaking endothelium allows iron and other blood components in, the immune system reacts to clean this up. There is an over reaction and some of the damage that is caused to the brain is a direct result of this immune system effort to clean up the lesion and repair.
It is known that in stroke a good portion of the damage is caused by immune system reaction to the stroke and the effort to clean up. They are now testing on mice to see if drugs they use to suppress immunity, some used in MS too, will help if given to stroke survivors temporarily.
Spinal cord injury same thing, a good portion of the damage comes from the immune effort to repair and clean up.
This answer goes for every kind of immune alteration there is: ASCT, hicy etc etc, although there may be some real differences in mechanism of action for individual drugs, Campath comes to mind there, ......and it is highly speculative of course as CCSVI is not at all proven and someone will need to look at those angles. I have confidence that the drug manufacturers will make a real effort to see how their drugs work with CCSVI should it become understood as the cause of MS.
But just to bolster the argument CVI, insufficiency in the legs is absolutely positively proven and they KNOW that inflammation causes a good part of the damage in that problem. CCSVI is the same thing but in the brain instead of the foot.
ALternatively, if CCSVI happens and then autoimmunity happens after the fact and THIS is a large part of damage in CCSVI, then all of these MS drugs "work" the way they are purported to work in the autoimmune model, it is just that ongoing damage by the venous problems keep the area damaged so it can't ever actually heal.
that is all hypothetical of course
I'm not offering medical advice, I am just a patient too! Talk to your doctor about what is best for you...
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