The fact that more severe malformations have been found in those with more progressive disease has been mentioned by Dr. Zivadinov in the BNAC studies. Disturbed blood flow has been found to change the lining of the arteries--
http://www.sciencedaily.com/releases/20 ... 140922.htm
Jo says that endothelial cells, which form the inner lining of blood vessels, are equipped with sensors that detect changes in fluid flow.
"Disturbed flow is what causes the endothelial cells to become inflamed," he says.
The inflammation resulting from "bad flow" conditions in a stretch of artery causes white blood cells to accumulate there, followed by buildup of cholesterol and lipids and plaque formation.
So, CCSVI would be considered a chronic and progressive disease, where altered blood flow would change the endothelium and worsen with age. Dr. BB Lee has also talked about how venous malformations grow as the body matures.
All this makes sense with what Dr. Simka and others are finding. As far as fatigue, Jeff and I have spoken with Dr. Dake regarding jugular stenosis and hypoperfusion leading to a low oxygen environment in the brain as an initiator in fatigue. Those with higher stenosis, more brain lesions and RRMS seem to suffer the most from debilitating fatigue.
We're still in the beginning days, but this is more evidence to the connection--
keep those paper coming!!!