EGCG, iron and the brain

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Postby sou » Mon Nov 09, 2009 7:00 am

NAC boosts the natural antioxidant capacity of the cells by increasing glutathione concentrations, which is one of the main natural antioxidant enzymes.

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Postby cah » Mon Nov 09, 2009 7:11 am

If I got it right, chelating is a process of "binding".

Just a thought, and maybe a stupid one: The stents are made of metal... is there a possibility that chelating meds could do any harm to the stent, or accumulate through binding at the stent or something?
Last edited by cah on Mon Nov 09, 2009 8:35 am, edited 1 time in total.
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Postby zap » Mon Nov 09, 2009 7:31 am

I am not sure about the extracts, but tea - especially cheaper green tea leaves, is incredibly high in sodium fluoride, which does seem to effect the BBB/endothelium.

http://www.google.com/search?q=tea+sodium+fluoride

http://www.google.com/search?q=endothel ... m+fluoride

I drink tea, but I avoid cheaper teas (made with older leaves) and drink in moderation.
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Postby ErikaSlovakia » Fri Nov 13, 2009 12:20 pm

wonky1 wrote:I love green tea, unfortunately it makes me vomit. I think I've damaged my stomach lining with one pill or another.


I have exactly same problem.
I can also get EGCG in Slovakia. I will choose something next week.
I think I can take it with Clexane as I do not have to do any changes in my diet. I am off the antibiotics as well, so I think it will be safe.
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse
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Postby harry1 » Mon Nov 23, 2009 2:59 pm

zap wrote:I am not sure about the extracts, but tea - especially cheaper green tea leaves, is incredibly high in sodium fluoride, which does seem to effect the BBB/endothelium.

http://www.google.com/search?q=tea+sodium+fluoride

http://www.google.com/search?q=endothel ... m+fluoride

I drink tea, but I avoid cheaper teas (made with older leaves) and drink in moderation.


That's what i also discovered in my research about Green Tea as it contains high amounts of fluoride as i was worried about consuming tons of that toxic mineral daily and so i assume the ECGC supplements are fluoride free correct?

Thanks everyone !!!
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Postby jimmylegs » Mon Nov 23, 2009 6:09 pm

zinc deficiency is linked to iron dysregulation and deposition.

ms patients are lower in zinc than controls.

average zinc levels in healthy controls, in several different studies, comes out to 18.2 umol/L.

optimizing your zinc levels can have several other benefits including:
- elevating uric acid (by converting toxic ammonia byproducts of digestion)
- apparently helps to increase d3 absorption
- increases intestinal impermeability due to strong tight junctions between cells
- toughens up that blood brain barrier
- can reverse some types of liver damage
- preventative against cancer
- sexy times

the list goes on...

JL
my approach: no meds so far - just nutrient-dense anti-inflammatory whole foods, and supplements where needed
info: www.whfoods.com, www.nutritiondata.com
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Re: EGCG, Iron and the brain

Postby NHE » Tue Nov 24, 2009 4:37 am

harry1 wrote:That's what i also discovered in my research about Green Tea as it contains high amounts of fluoride as i was worried about consuming tons of that toxic mineral daily and so i assume the ECGC supplements are fluoride free correct?

Thanks everyone !!!


The following posts may be of interest if you haven't already seen them yet. They discuss fluoride and tea.


I hope these are helpful.

NHE
Last edited by NHE on Sun Nov 29, 2009 6:11 am, edited 2 times in total.
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Postby harry1 » Tue Nov 24, 2009 12:04 pm

Thanks Jimmylegs and NHE as i really do appreciate your info the posted links as i'll check them out !!

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Postby gibbledygook » Tue Nov 24, 2009 12:25 pm

Wonky1, have a look in pubmed. I found this there:

Clin Exp Pharmacol Physiol. 2009 Jul;36(7):612-8.

Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.
Lou LX, Geng B, Chen Y, Yu F, Zhao J, Tang CS.

Institute of Cardiovascular Diseases, Peking University First Hospital, Beijing, China.

1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-induced cellular injury. 2. Iron overload in rats was generated by intraperitoneal injection of iron-dextran chronically (30 mg/kg per day for 9 weeks) or acutely (300 mg/kg once). Tissue injury was assessed by determining serum lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, as well as malondialdehyde (MDA) content in the heart and liver. The ER stress response was analysed by expression of glucose-response protein 78 (GRP78) and activation of caspase 12. 3. In chronic iron-loaded rats, iron levels in the heart and liver were higher, by approximately 2- and 7.8-fold, respectively (P < 0.01), compared with control. Serum LDH, ALT and AST activity, as well as MDA content, GRP78 expression and caspase 12 activity in the heart and liver, were upregulated in chronically iron-loaded rats. In acute iron-loaded rats, iron content in the heart and liver was 51% and 63% higher than in controls (both P < 0.01). Serum LDH, ALT and AST activity, MDA content in the heart and liver and levels of ER stress markers were all increased in acute iron-loaded rats. N-Acetylcysteine (150 mg/kg, s.c.) lowered the levels of these parameters in acute iron-loaded rats. 4. The results of the present study indicate that ER stress may play an important role in iron-induced tissue injury and that reactive oxygen species may mediate the ER stress response in the pathogenesis of iron-overload cellular injury.

PMID: 19594550 [PubMed - in process]
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Postby ErikaSlovakia » Fri Nov 27, 2009 1:19 pm

I have ordered this EGCG/Teavigo in England today:
http://www.iherb.com/Healthy-Origins-Te ... 0YYkw&at=0
The price was 12,53 Euro (Euro is strong against the pound now).
The Teavigo from Czech Republic is only 25 mg.
Both are 60 capsules. The Czech stuff costs 17,90 Euro.

So, I will see.
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse
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mercury and iron chelators likely to be different

Postby hwebb » Sun Nov 29, 2009 3:45 am

Hi there,

just a comment to Wonky1...who indicated that a good chelator for mercury may be a good chelator for iron. I think this is an incorrect assumption.
The common valency for mercury: Hg(I), Hg(II)
The common valency for Iron: Fe(I), Fe(II), Fe(III)

In addition to having a different number of available binding sites, each is a different size. Each also belongs to a different chemical group (chemicals in the same group often exhibit similar behavours).

I don't know much (anything) about the chemcial structure of the chelator you're using...but it's probably best to try to target one specifically designed to bind to iron.

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Postby AndrewKFletcher » Sun Nov 29, 2009 4:16 am

Drinking peppermint tea, or taking peppermint oil capsuals could prove very useful for a damaged stomach and intestine lining.

Chilli works differently and causes a mucus that insulates the damaged area.

Might be worth researching both.

We drink rainwater filtered through sediment filters and ultimately a ceramic candle filter.

The tea tastes amazing and rainwater is free of most chemicals and solutes so serves to reduce contaminents in diet.

Bathing in rainwater alsos highly recommended

Andrew
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Postby ErikaSlovakia » Sun Dec 27, 2009 9:24 am

So I have my EGCG Teavigo capsules at home.
I have odered it by iherb in England. It is Caffeine free, 90% EGCG, 150 mg.
I plan to start to take 2 capsules a day in a week. I still have to inject 6 Clexane injections and I have got flu.
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse
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Postby cheerleader » Sat Feb 06, 2010 5:17 pm

BUMP- please read regarding iron-
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Rokkit » Fri Sep 17, 2010 8:08 am

Bumping this again due to the recently renewed interest in the 2003 iron in the brain paper.
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