Possible animal model for MS by inducing CCSVI ?

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Possible animal model for MS by inducing CCSVI ?

Postby ozarkcanoer » Sun Nov 01, 2009 8:38 pm

One of the problems with the scientific study of MS is the lack of an animal model of the disease. Now with CCSVI, it seems like scientists can cause stenosis by clamping the jugulars and/or azygous of mice (do mice have them ???) to force reflux. Then see if lesions develop. Seems like a good idea to me !!!! Any thoughts ????

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Postby bestadmom » Sun Nov 01, 2009 8:43 pm

Mice have a short life span. I wonder if the damage from hypoxia would be seen in such a short period of time, or if it is accellerated to correspond with their short lives. I bet you will find out lots about this on Weds.
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Postby cheerleader » Sun Nov 01, 2009 8:45 pm

Dr. Cooke and his team are working on an appropriate mouse model at Stanford. Stay tuned!
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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby ozarkcanoer » Sun Nov 01, 2009 8:48 pm

I'm so glad to hear this !!!!!! Dr. Cooke..... hmmmm, I haven't heard the name yet. If they come up with an appropriate mouse model then the whole process from stenosis to reflux to blood/brain barrier to iron deposits to immune response, etc etc. MS will be completely solve lickety-split !!
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Postby cheerleader » Sun Nov 01, 2009 8:56 pm

ozarkcanoer wrote:I'm so glad to hear this !!!!!! Dr. Cooke..... hmmmm, I haven't heard the name yet. If they come up with an appropriate mouse model then the whole process from stenosis to reflux to blood/brain barrier to iron deposits to immune response, etc etc. MS will be completely solve lickety-split !!

Dr. Cooke is the endothelial researcher at Stanford...his book, The Cardiovascular Cure, was an inspiration to me in setting up Jeff's program. I sent him Dr. Zamboni's research, he gave it to Dr. Dake and put us in touch. His work has been in modeling endothelial disruption in cardiovascular disease. He is fascinated by CCSVI, and joining the journey. He said he'dlet me know when he gives those mice CCSVI.
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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animal model

Postby GiCi » Mon Nov 02, 2009 8:17 am

If we think that the defective drainage of venous blood from the brain is mainly due to congenital (present at birth) narrowing of the jugular and/or azygos veins, and that MS develops at least 30 years after birth, and can slowly progress for 30-40 years after its onset, the only effective animal model I can think of would be using elephants.
I am not a scientist, and I expressed only what makes sense for me.
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Re: animal model

Postby cheerleader » Mon Nov 02, 2009 9:21 am

GiCi wrote:If we think that the defective drainage of venous blood from the brain is mainly due to congenital (present at birth) narrowing of the jugular and/or azygos veins, and that MS develops at least 30 years after birth, and can slowly progress for 30-40 years after its onset, the only effective animal model I can think of would be using elephants.
I am not a scientist, and I expressed only what makes sense for me.
GiCi


Agreed, GiCi. I expressed similar concern with lifespan and progression to Dr. Cooke, and he said they have ways to extrapolate information and speed lifespan and disease progression in the lab.
We'll see!
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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