Ernst wrote:"Biochemicly Zamboni's theory can't be right about iron accumulation, cause iron is in red-cells and redcells has to break to release iron.. and there is no proof of that"
jimmylegs wrote:yes iron is in the hemoglobin of RBCs...
from what i understand, RBCs have a life span. at the end of it, they 'break'. specialized macrophages scavenge the iron in the hemoglobin and move it to other cells via transferrin etc.
if you look at haacke's imaging you can see differences btw brain iron in ms and normal subjects - visit http://www.ms-mri.com
so why the iron accumulation in ms brains... well here is one line of thinking:
-ms patients have lower zinc than normal controls (which in turn can affect vit d3 absorption and uric acid status, also abnormal in ms patients)
-zinc deficiency appears to be able to cause dysregulation and deposition of iron
-low zinc seems to exacerbate low iron levels and vice versa...
-the blood brain barrier has been shown to be weakened in zinc deficiency (although i did find one abstract today suggesting the bbb has some ways to resist the effects of zinc deficiency)
so maybe the various effects of zinc deficiency combine to contribute to iron deposition in ms brain tissue.
1eye wrote:Apparently osmosis can move liquids around, without any other impelling force. I am skeptical and remain agnostic on that one.
Potential Conflicts of Interest
S.P.: travel expenses, Biogen Idec, Teva. W.B.: board membership, Teva Pharma, Biogen Idec, Genzyme, Novartis; consultancy, Teva Pharma, Biogen Idec, Novartis, Genzyme; grants/grants pending, Teva Pharma, Biogen Idec, Novartis; speaking fees, Teva Pharma, Biogen Idec, Merck Serono, Novartis, Bayer Vital, Sanofi, Genzyme. H.L.: consultancy, Amgen, Biogen, Baxter; speaking fees, Novartis, BiAogen Idec, Serono, Teva.
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