Cause or Consequence?

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Cause or Consequence?

Postby Johnnymac » Tue Dec 01, 2009 4:40 pm

I’ve seen the argument thrown out in quite a few quotes by the overly and cautiously skeptic medical professionals who have been quoted in various articles. CCSVI can be concretely proven to be present with simple imaging tests, its hard evidence of a physical malformation that can’t be disputed, so the next logical platform for the skeptics will be “We can’t say for sure if CCSVI is a trigger for MS or an additional symptom/result of MS.” Regardless, that argument shouldn’t have any bearing on people being treated for CCSVI, but it’s going to be something that will have many heated debates and one that will be fueled by pharmas who risk losing billions in revenue from more traditional MS symptom and disease modifying drugs.

My question would be, if by treating CCSVI the progression of MS halts (permanently as long as constrictions don’t re-occur), does that in and of itself prove it’s the trigger and not a symptom? If that’s the case, does that mean that new MS diagnosis will instead be CCSVI diagnosis and term MS will go away all together?
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Postby cheerleader » Tue Dec 01, 2009 4:59 pm

The brilliance of D. Zamboni's postulation and subsequent research was that he looked at THE BODY AS A WHOLE. He didn't isolate the brain from the rest of the body. He knew how venous reflux and stenosis created damaging plaques in other parts of the body. He understood how stagnation and reflux of blood created hypoxic damage and iron deposition in chronic venous disease. And in chronic venous disease, the stenosis comes first, reflux follows and lesions are the result. This is the model for CCSVI.

In 1863, Rindfleisch looked at autopsy brains from MS patients (before they were called multiple sclerosis patients) and saw an engorged vein inside every single lesion. He called this disease one of "venous congestion."
The fact that it has taken 140 years for doctors to look just inches below the brainstem is astounding to me. I believe venous stenosis and reflux is the beginning of the MS plaque process, just as venous stenosis starts the problem in the spine, legs, liver, etc. We have the research to prove the link in the rest of the body, and we are compiling the research to confirm it in the brain. But the fact remains, It is one body.

In other chronic venous disease, repairing the veins ends the disease process. The hope is it will be the same in CCSVI. Dr. Zamboni's wife is 3 years out from treatment, my husband is 7 months. Neither of them have had progression of MS, as evidenced by no relapses or new lesions. Only time will tell the rest,
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
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Postby ozarkcanoer » Tue Dec 01, 2009 5:22 pm

cheer, you should have been a researcher. I guess you ARE a researcher, LOL. I like your last post. I call it "CCSVI in a nutshell". :D :D
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