The brilliance of D. Zamboni's postulation and subsequent research was that he looked at THE BODY AS A WHOLE. He didn't isolate the brain from the rest of the body. He knew how venous reflux and stenosis created damaging plaques in other parts of the body. He understood how stagnation and reflux of blood created hypoxic damage and iron deposition in chronic venous disease. And in chronic venous disease, the stenosis comes first, reflux follows and lesions are the result. This is the model for CCSVI.
In 1863, Rindfleisch looked at autopsy brains from MS patients (before they were called multiple sclerosis patients) and saw an engorged vein inside every single lesion. He called this disease one of "venous congestion."
The fact that it has taken 140 years for doctors to look just inches below the brainstem is astounding to me. I believe venous stenosis and reflux is the beginning of the MS plaque process, just as venous stenosis starts the problem in the spine, legs, liver, etc. We have the research to prove the link in the rest of the body, and we are compiling the research to confirm it in the brain. But the fact remains, It is one body.
In other chronic venous disease, repairing the veins ends the disease process. The hope is it will be the same in CCSVI. Dr. Zamboni's wife is 3 years out from treatment, my husband is 7 months. Neither of them have had progression of MS, as evidenced by no relapses or new lesions. Only time will tell the rest,
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09