This Is MS Multiple Sclerosis Community: Knowledge & Support

Hi all

I'm having a hard time keeping up here so if this has already been posted...my apologies--it's recent research indicating there are iron related changes in people who've not yet been diagnosed with MS (CIS).

Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis


And, there's also this research--which found changes in brain iron metabolism correlated with disease progression.

Transcranial brain sonography findings predict disease progression in multiple sclerosis


Take care all....it's such an exciting time. Thanks to all who are contributing so much to the advances we're witnessing.

Sharon

Thanks, Sharon-
Terrific research, as usual.
These are both new studies published this fall...and not from Dr. Haacke or NYU...our usual gray matter investigators. It is interesting to see this research spreading across the globe. Gray matter changes appear to happen early in the MS process, and continue as the disease progresses. These studies further corroborate Dr. Zamboni's findings.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

What I find interesting about that quote is the implied acceptance of the fact that iron related changes are simply a part of the picture we all know about.

HERE'S A PAPER FROM '02



So to me the question is why all the mystery and head scratching about iron among people/neuros specifically newly hearing about CCSVI? This work relating iron as the big deal is OLD news...

If someone is trying to suggest that reflux and venous insufficiency is somehow only theoretically able to cause iron deposition and thus this is all a totally unknown mystery then they need to think about reading about venous ulcers


that one from 1988 paper

If refluxing blood and venous insufficiency in the legs causes iron deposition they why wouldn't it in the head??
just MHO

_________________
I'm not offering medical advice, I am just a patient too! Talk to your doctor about what is best for you...
http://www.thisisms.com/ftopic-7318-0.html This is my regimen thread
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Marie

I hear you on that one.

And, while the work with regard to iron is old news, I think the fact that they found iron deposition in clinically isolated syndrome (i.e., prior to diagnosis) is news. The neurodegeneration is present from the gitgo and doesn't just start to develop after 10-15 years of inflammation. That might be news to some neuros.

Marie

Great question....

Have a great day all

Sharon

With all this info on iron shouldn't the CCSVI 'protocol' include some sort of iron chelating process along with opening the veins to help remove it? And for those of us waiting for the procedure, should we perhaps be working on chelation while we wait?
Caution though - I did notice in my IP6 reading that it shouldn't be used in the weeks prior to and immediately after surgery as it does inhibit clotting (WebMD).