I'm having a hard time keeping up here so if this has already been posted...my apologies--it's recent research indicating there are iron related changes in people who've not yet been diagnosed with MS (CIS).
Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis
Gray matter (GM) magnetic resonance imaging (MRI) T2 hypointensity, a putative marker of iron deposition, is a frequent finding in patients with clinically definite (CD) multiple sclerosis (MS).
The objective of this study was to assess: (a) how early deep GM T2 hypointensity occurs in MS, by studying patients with clinically isolated syndromes (CIS) suggestive of MS, and (b) whether they contribute to predict subsequent evolution to CDMS
In CIS patients, deep GM is not spared, suggesting that iron-related changes and neurodegeneration occurs early. The magnitude of such damage is only minor and not associated with an increased risk of evolution to CDMS.
And, there's also this research--which found changes in brain iron metabolism correlated with disease progression.
Transcranial brain sonography findings predict disease progression in multiple sclerosis
CONCLUSIONS: Neurodegenerative disease-like deep gray matter lesions can be frequently detected by transcranial sonography (TCS) in patients with multiple sclerosis (MS). Findings suggest that TCS shows changes of brain iron metabolism which correlate with future progress of MS
Take care all....it's such an exciting time. Thanks to all who are contributing so much to the advances we're witnessing.