patientx wrote:That's exactly my point. It's a feasible theory. But little has been shown to prove that iron is being deposited because of the stenosis. According to Zamboni, the vein stenosis is unique to MS. Yet, iron accumulation in the brain has been shown in other neurological diseases, like Parkinson's and Alzheimer's. Maybe, the iron accumulation results from the death of brain cells, and not direct deposition from the blood.
Really good point, Patientx. We do know about iron deposition in other neurological diseases. The iron in Alzheimers, Parkinsons and Huntingtons is found mainly in the basal ganglia, where death of cells due to a malfunction in neural transmitters is thought to be behind the iron deposition. But Multiple Sclerosis iron deposition looks very different than these diseases, in the fact that ms lesions are formed along the veins (periventricular) and typically in the region known as the corpus callosum. Here's some more of Dr. Zamboni's research on the unique location of iron deposition and lesions in the MS brain-
In MS, plaques are venocentric, involving, almost invariably, a
periventricular vein or other major segments of the dMCVs
(Frohman et al., 2006; Barnett et al., 2006; Tan et al., 2000; Kidd et
al., 1999; Kermode et al., 1990; Schelling, 1986; Fog, 1965). The
main finding of our study is the detection of altered haemodynam-
ics just in veins anatomically related to MS lesions, causing a high
rate of reverse flow with a chaotic displacement of blood at the
activation of the thoracic pump, which is never seen in controls.
Finally, the severity of venous reflux can be also expressed by
the extent of its distal propagation. In our study the involvement of
veins of the subcortical grey matter was significantly associated
with the worse disability scores of our MS population (Fig. 4, Fig.
5). If confirmed, this finding could become a clinical indicator of
disease progression. imaging of iron deposition in neurological disorders.
http://www.bentham.org/cnr/openaccessar ... /004AG.pdf
We know that venous reflux creates iron deposition into tissue in the legs in CVI, and in the liver in Budd Chiari. Why wouldn't venous stenosis and reflux act the same way in the brain? It's really not a matter of belief, it's just science.
The very first scientist to study MS lesions, Rindfleisch, noted an engorged vein at the center of each lesion. He just used a microscope in the 1800s.