A doctor posted the following comment with some intelligent questions concerning the CCSVI theory on the Buffalo News web site article. I posted a quick answer that they are finding pressure gradients across stenosis and they are finding problems with the azygous vein, but perhaps some people have some better answers for him.
If Dr. Zamboni's hypothesis is correct then why don't patients with MS show signs of increased intracranial pressure (which they should have if venous drainage from the brain is impeded) and why is the so-called "opening pressure" that is measured at routine lumbar punctures not increased in MS patients? Conversely, why do patients who develop blood clots in large venous structures on the surfaces of the brain (called the "venous sinuses") not develop MS afterwards? MS patients have plaques all over the spinal cord - are all those draining veins abnormal, too, and need to have an angioplasty? And moreover, there are quite a few possible explanations for iron deposits other than venous blockage.
As a general principle, 'correlation' never proves 'causation' - an extremely important point to keep in mind always.
There are many unanswered questions about this - admittedly ingriguing - hypothesis, and I applaud Dr. Zivadinov and others who will get us some answers.
And before I'm dismissed by the posters and bloggers as yet one more heartless physician who doesn't understand how patients "feel" - I happen to have MS myself for over 10 years now.
We all want to get rid of this nasty disease, but wishful thinking isn't going to get us there - we need data and proper studies. Don't just give in to the cycles of hope and fear!
Karl F. Gross, MD
First point: No doctor will ask the public questions such as these. These questions are rhetorical and asked maliciously
2. No well-intentioned doctor will ask such dumb questions
3. I don't believe for one second that this doctor has MS
4. If this dude has MS AND he's a doctor, he would know a lot more about MS and CCSVI
5. This guy is playing interference
BTW feller: High ICP isn't caused by blood, plaques do not occur where the stenosis is, and clots are not oxidative
He just wanted to make a sarcastic comment about people being sick of the medical profession. His feelings are hurt and he thinks we're impolite.
Must be quite the shock though. Have you ever watched the types that go on these TV small claims court shows? They are in utter denial when they get found out. Pathologically infantile.