conversion fyi: Ferritin ng/mL 2.247 pmol/L
i agree 200% about reference ranges being crap.
when you have chronic illness you can have ferritin readings come back higher than they actually are, without having haemochromatosis. 'anemia of chronic disease'
Molecular pathogenesis of anemia of chronic disease
Most patients suffering from chronic infections, chronic inflammatory diseases, and some malignancies develop a mild to moderate anemia designated anemia of chronic disease or anemia of inflammation. Patients with this anemia have low serum iron, low to normal transferrin, and high to normal serum ferritin concentration. The anemia is caused by increased inflammatory cytokines, especially IL-6, inducing increased production of the iron-regulatory hormone hepcidin by hepatocytes. Hepcidin blocks the release of iron from macrophages, hepatocytes, and enterocytes, causing the characteristic hypoferremia associated with this anemia and iron-deprivation of the developing erythrocytes
personally i tend to the low end on the ferritin results.. my last one was improved, i'm at 91 on a scale of 10-291, i am ASSUMING that's in pmol/L but not 100% sure because the printout from life labs does not say..
anyway that's up from 82 in 2007 (at that time the scale according to my lab was 51-140, apparently a few extremists have weighed in since then)
i have an iron level kicking around somewhere but i seem to be missing a page of results out of my file, if i find it i'll relay
Chronic disorders are frequently accompanied by impairment of iron metabolism2. There are various blood tests that can be done to elucidate iron deficiency in RA, including serum ferritin, mean corpuscular volume (MCV), and serum transferrin receptor levels, as reviewed by Swaak. The serum ferritin level is not a reliable indicator of iron deficiency, as it is an acute phase reactant and the level may be elevated in RA. MCV can also be affected by the second-line treatment for RA (e.g., azathioprine, salazopyrin, methotrexate), which can increase the MCV. Coexisting morbidity (e.g., hypothyroidism, B12, folate deficiency, and alcohol abuse) could also influence results.
The use of ZPP level in blood to diagnose iron deficiency anemia in RA has received limited attention. Red cell precursors normally synthesize slightly more protoporphyrin than is needed for heme synthesis. The excess remains with the cell throughout its lifespan and has been called free erythrocyte protoporphyrin (FEP). When iron is not available for heme synthesis protoporphyrin accumulates in excess as zinc protoporphyrin. The level of FEP increases dramatically in iron deficiency and is a sensitive laboratory abnormality2.
The ZPP determination is simple and also appears to provide a sensitive index of iron-deficient erythropoiesis3. Currently it is used to differentiate between iron deficiency, beta thalassemia, and lead poisoning4. ZPP level is also used as a screening tool for iron deficiency anemia in hospitalized patients5.
ZPP levels are elevated in iron-deficient erythropoiesis, which can be associated with iron deficiency and anemia of chronic diseases
not sure how this would pan out in ms-ers, who tend to be lower in zinc than healthy controls (and therefor low in uric acid)