I researched as many endothelial disrupters as I could from online research papers in October 2008, and came up with a long list-
oxidative stress, saturated fats, glucose, sedentary lifestyle, low vitamin D, low vitamin B12, smoking, heavy metals (esp. mercury and cadmium), air pollution (especially diesel exhaust), arsenic and chlorine in water, sleep deprivation, chronic bacterial infections, viruses, over-exposure to electro-magnetic fields, pcbs in plastic. A veritable laundry list of 21st century life.
Here's the paper: